Proteomics Research and Its Possibility of Application in Endometriosis

Ningning Wang
In: Molecular Bases of Endometriosis - The Integration Between Research and Clinical Practice · 2019 · doi:10.5772/intechopen.81850 · W2913814243
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Proteomics can analyze various sample types to identify differential protein expression, potentially yielding noninvasive diagnostic markers and treatment targets for endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This paper reviews the use of proteomics to identify differential protein expression linked to endometriosis, focusing on how sensitive mass-spectrometry approaches can profile serum, peritoneal fluid, and tissue to uncover candidate biomarkers and therapeutic targets, including cytokines and growth factors involved in implantation, angiogenesis, invasion, and hormone regulation. It summarizes protein-level evidence across hormone signaling changes, angiogenic factors such as VEGF-related pathways, extracellular matrix remodeling involving MMPs/TIMPs, and discussions of endometriosis’s possible neoplastic behavior with malignant transformation–associated molecular alterations. The paper also highlights inflammatory mediators in peritoneal fluid and plasma produced by immune and endometrial cell types, tying these proteins to processes that amplify lesion establishment. As a narrative review rather than a proteomics study with original datasets, it does not provide a unified experimental method or explicit diagnostic validation across populations. This paper is centrally about endometriosis — it surveys proteomics research and related protein pathways as routes to noninvasive diagnostics and treatment targets in endometriosis.

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Abstract

The onset search for differential protein expression in endometriosis commenced more than 30 years ago, when the gel electrophoresis could not be available to distinguish serum from women with and without disease. Gradually as the proteomics allows the comprehensive analysis of peritoneal fluid, serum and tissue samples with good sensitivity and resolution, it has promised in delivering markers possibility associated with endometriosis. Cytokines and growth factors that are present in serum, peritoneal fluid, endometrium, endometriotic lesions tissues and involved in tissue implanting process including hormone regulation, angiogenesis, invading and malignancy may be the focus to develop the noninvasive diagnostic test and possible treatment target for endometriosis. Individual peptides or proteins that are present or absent (or up- or down-regulated) in various conditions can be assessed as possible biomarkers. Alternatively, proteomic profiling, using mass spectrometry in combination with bioinformatics software to identify the actual protein and peptide pattern can be used as a distinctive marker to diagnostic and treatment target contribution to the disease.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (94)

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