Genetic Alterations in Microsatellite Marker Sites among Tumor Suppressor Genes in Endometriosis

K Nakayama, Kuniaki Nakayama, T Toki, Toshihiko Toki, Toshio Nikaido, T Nikaido, Y L Zhai, Ya-Li Zhai, I Konishi, Ikuo Konishi
Gynecologic and obstetric investigation · 2001 · vol. 51(4) , pp. 240–242 · doi:10.1159/000058057 · PMID:11408734 · W1981116543
article OA: closed CC0 ⤵ 10 in-corpus citations
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This study examined four endometriotic lesions for genetic alterations in microsatellite marker sites of eight tumor suppressor genes, finding only one instance of loss of heterozygosity at the PTCH locus.

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Abstract

Four endometriotic lesions were examined for the presence of genetic alterations in microsatellite marker sites among eight tumor suppressor genes. For this, a microdissection method was used on paraffin sections. Only one instance of loss of heterozygosity was detected at the PTCH locus. Heterozygosity was retained (indicating the absence of both loss of heterozygosity and microsatellite instability) at the other seven tumor suppressor gene loci in all the cases. Among the tumor suppressor genes examined, genetic defects in these microsatellite regions are certainly not ubiquitous in endometriosis and may be uncommon.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Genes, Tumor Suppressor Microsatellite Repeats Mutation Adult Endometriosis Female Genes, Tumor Suppressor Humans Loss of Heterozygosity Membrane Proteins Membrane Proteins Middle Aged Patched-1 Receptor Patched Receptors Receptors, Cell Surface

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References (13)

Cited by (10)

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