Vascular endothelial growth factor A and C gene expression in endometriosis

Mikio Takehara, Takehara M, Ueda M, Masatsugu Ueda, Yamashita Y, Yoshiki Yamashita, Yoshito Terai, Terai Y, Yao-Ching Hung, Yao‐Ching Hung, Hung YC, Ueki M, Minoru Ueki
Human pathology · 2004 · vol. 35(11) , pp. 1369–1375 · doi:10.1016/j.humpath.2004.07.020 · PMID:15668894 · W2168963576
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This study investigated the expression levels of vascular endothelial growth factor A and C genes in endometriosis tissues and found differential expression patterns.

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Abstract

Angiogenesis is essential for the pathogenesis of endometriosis. Gene expression levels of vascular endothelial growth factor (VEGF) A and C in 10 eutopic endometrial, 23 normal peritoneal, and 62 endometriotic tissues surgically obtained from 47 women with endometriosis (group 2) were compared with those in 12 control eutopic endometrial and 9 normal peritoneal tissues from 15 women without endometriosis (group 1). VEGF-A mRNA expression levels in eutopic endometrium of group 2 were higher than those of group 1 throughout the menstrual cycle (P <0.01) and increased in the secretory phase. VEGF-A gene expression in peritoneal endometriotic lesion was statistically higher than that in normal peritoneum (P <0.01) and similar to that in eutopic endometrium of group 2. In contrast, gene expression levels of VEGF-C were relatively lower than those of VEGF-A in each lesion, and no cyclic variation was found. VEGF-A and C mRNA expression levels were significantly higher in ovarian endometriomas >6 cm in size than in those <6 cm in size. Immunohistochemical expression of VEGF-A and C was detected in the cytoplasm of glandular epithelial and stromal cells of ovarian endometrioma. These results suggest that endometriosis may arise from eutopic endometrium with higher levels of angiogenic activity possibly induced by VEGF-A in women with endometriosis. Moreover, VEGF-C as well as VEGF-A may be involved in the pathogenesis of ovarian endometrioma.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor C DNA Primers DNA Primers Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Immunoenzyme Techniques Menstrual Cycle Menstrual Cycle Neovascularization, Pathologic Peritoneum

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