Expression of the vascular endothelial growth factors B and C and their receptors in human endometrium during the menstrual cycle

Björn Möller, Bo Lindblom, Matts Olovsson
In: Acta Obstetricia et Gynecologica Scandinavica · 2002 · vol. 81(9) , pp. 817–824 · doi:10.1034/j.1600-0412.2002.810903.x · PMID:12225295 · W2040259281
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Vascular endothelial growth factors B and C and their receptors were expressed in human endometrium, with VEGFR-2 showing increased expression in the early secretory phase, suggesting a role in endometrial angiogenesis.

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Abstract

BACKGROUND: Endometrial angiogenesis is important for bleeding control and fertility, and is believed to be regulated by angiogenic growth factors under the influence of ovarian steroids. OBJECTIVE: To document the pattern of expression of the two angiogenic growth factors, vascular endothelial growth factor (VEGF)-B and VEGF-C, and of their receptors, VEGFR-1, VEGFR-2, and VEGFR-3, in order to investigate their possible role in the regulation of angiogenesis in normal cycling human endometrium. MATERIAL AND METHODS: Cryosections of endometrial biopsy specimens obtained from 17 healthy women before laparoscopic sterilization were examined by immunohistochemistry. RESULTS: Vascular endothelial growth factor and VEGF-C and their receptors were all expressed in and around endometrial blood vessels, with no obvious menstrual cycle-dependent changes in expression except for VEGFR-2, which showed stronger expression during the early secretary phase. Stromal blood vessel density did not change significantly during the menstrual cycle. CONCLUSION: The presence and pattern of expression of these angiogenic growth factors and their receptors suggest that they participate in the regulation of normal endometrial angiogenesis.

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