Human pathology

Hum Pathol · ISSN (e) 1532-8392 · 47 papers in corpus
other 2025
Intestinal and liver involvement by endometrial stromal sarcoma: Expanding the differential diagnosis of mesenchymal tumors involving the GI tract
doi:10.1016/j.humpath.2025.105784 ·PMID:40319947

Endometrial stromal sarcoma (ESS) is a mesenchymal tumor known for infiltrative growth and lymphovascular invasion. Most examples arise in the endometrium, but some occur in the abdominal cavity without a primary uterine lesion, likely orig…

article 2025
The occurrence and histopathological recognition of atypical endometriosis in patients with ovarian endometriosis – a retrospective cohort study
doi:10.1016/j.humpath.2025.105875 ·PMID:40706757
other 2021
Detection of MED12 mutations in mesenchymal components of uterine adenomyomas
doi:10.1016/j.humpath.2020.11.013 ·PMID:33259844

Adenomyoma of the uterus is a biphasic nodular lesion composed of a mesenchymal component with smooth muscle differentiation and a glandular epithelium. The neoplastic nature of uterine adenomyomas has been controversial because some are co…

other 2021
Expression of uroplakin II and GATA-3 in bladder cancer mimickers: caveats in the use of a limited panel to determine cell of origin in bladder lesions
doi:10.1016/j.humpath.2021.04.005 ·PMID:33887302

Antibodies targeting uroplakin II (UPII) are highly specific for urothelial cells and are frequently used to determine if a primary bladder lesion or a metastatic lesion originates from the urothelium. However, to date, no studies have test…

article 2021
Intravascular adenomyomatosis: a morphologic variant of intravenous leiomyomatosis associated with endometriosis and potential for misdiagnosis
doi:10.1016/j.humpath.2021.11.009 ·PMID:34856302
other 2020
High glypican-3 expression characterizes a distinct subset of ovarian clear cell carcinomas in Canadian patients: an opportunity for targeted therapy
doi:10.1016/j.humpath.2020.01.002 ·PMID:32017945

The expression frequency and distribution of glypican-3 (GPC3) was retrospectively assessed by immunohistochemistry in 316 accurately phenotyped ovarian clear cell carcinoma (OCCC) specimens from Canadian patients. The study aimed to evalua…

article 2019
Alterations in β-catenin, microsatellite instability, and HNF-1β levels are independently associated with ovarian endometriosis–associated tumorigenesis
doi:10.1016/j.humpath.2019.04.001 ·PMID:31022415
article 2019
Clinicopathologic findings in gynecologic proliferations of the appendix
doi:10.1016/j.humpath.2019.08.004 ·PMID:31430494
article 2018
Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis
doi:10.1016/j.humpath.2018.10.028 ·PMID:30447298
review 2018
Ovarian carcinomas: at least five different diseases with distinct histological features and molecular genetics
doi:10.1016/j.humpath.2018.06.018 ·PMID:29944973
other 2018
Refractory inflammatory bowel disease: is there a role for Epstein-Barr virus? A case-controlled study using highly sensitive Epstein-Barr virus-encoded small RNA1 in situ hybridization
doi:10.1016/j.humpath.2018.08.001 ·PMID:30120969

A potential role for viral infections has been implicated in inflammatory bowel disease (IBD) unresponsive to medical treatment. It is well known that Epstein-Barr virus (EBV) infection can elicit a brisk mononuclear response in the gastroi…

article 2017
Expression of protease-activated receptor-2 (PAR-2) is related to advanced clinical stage and adverse prognosis in ovarian clear cell carcinoma
doi:10.1016/j.humpath.2017.04.008 ·PMID:28438620
article 2017
Postablation neuroma of the myometrium—a report of 5 cases
doi:10.1016/j.humpath.2017.08.013 ·PMID:28843713
other 2014
Endometrial cysts within the liver: a rare entity and its differential diagnosis with mucinous cystic neoplasms of the liver
doi:10.1016/j.humpath.2013.11.005 ·PMID:24491354

Endometrial cysts within the liver are rare but can present as diagnostic challenges on small biopsies or frozen sections and may mimic mucinous cystic neoplasms (MCN) of the liver. Five cases of endometrial cysts and 6 cases of MCNs within…

review 2013
Epithelial-to-mesenchymal transition and stem cells in endometrial cancer
doi:10.1016/j.humpath.2013.04.009 ·PMID:23845467

This review article describes the main features of epithelial-to-mesenchymal transition (EMT) and its possible role in understanding myometrial invasion in endometrial carcinoma (EC), as well as the development of malignant mixed Müllerian …

article 2012
HMGA gene rearrangement is a recurrent somatic alteration in polypoid endometriosis
doi:10.1016/j.humpath.2011.09.013 ·PMID:22221703
article 2012
Involvement of pelvic inflammation–related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis
doi:10.1016/j.humpath.2012.02.005 ·PMID:22626277
article 2012
KRAS mutations in ovarian low-grade endometrioid adenocarcinoma: association with concurrent endometriosis
doi:10.1016/j.humpath.2011.10.009 ·PMID:22305241
article 2011
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis
doi:10.1016/j.humpath.2011.06.020 ·PMID:21944080
article 2011
Intravenous leiomyomatosis of the uterus
doi:10.1016/j.humpath.2010.10.015 ·PMID:21777942
review 2011
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm
doi:10.1016/j.humpath.2011.03.003 ·PMID:21683865

Recent morphologic, immunohistochemical, and molecular genetic studies have led to the development of a new paradigm for the pathogenesis and origin of epithelial ovarian cancer based on a dualistic model of carcinogenesis that divides epit…

other 2010
Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma
doi:10.1016/j.humpath.2009.10.011 ·PMID:20060152

Although clear cell adenocarcinoma have been described focally mimicking nephrogenic adenoma, we have identified a subset of clear cell adenocarcinoma that diffusely resembles nephrogenic adenoma (nephrogenic adenoma-like clear cell adenoca…

other 2009
Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumors
doi:10.1016/j.humpath.2008.12.006 ·PMID:19269675

Mullerian mucinous borderline tumor and gastrointestinal mucinous borderline tumor are considered mucinous tumor subtypes. However, it has been reported that mullerian mucinous borderline tumor shares many clinicopathologic features with se…

other 2008
CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium
doi:10.1016/j.humpath.2008.02.006 ·PMID:18619643

The major differential diagnostic problem presented by atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) (APA), which usually affects young women, is the exclusion of well-differentiated endometrial carcinoma invading the myo…

other 2008
Ureteral endometriosis: clinicopathological and immunohistochemical study of 7 cases
doi:10.1016/j.humpath.2007.11.011 ·PMID:18538172

Ureteral endometriosis is a rare yet important entity that can lead to renal failure due to silent obstruction of the ureter. Awareness of clinical and morphologic features can help in early detection and treatment. We analyzed the clinical…