Proteomic analysis of peritoneal fluid in fertile and infertile women with endometriosis.
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Peritoneal fluid proteomic analysis revealed differential expression of proteins, primarily involved in immune response, between fertile and infertile women with endometriosis.
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Abstract
OBJECTIVE: To evaluate the peritoneal fluid (PF) proteome of fertile and infertile women with endometriosis. STUDY DESIGN: PF samples were collected at laparoscopy from 26 fertile women and 26 infertile ones. Samples were subjected to 2-dimensional gel electrophoresis and compared by computerized analysis. Protein spots were identified by liquid chromatography tandem mass spectrometry. RESULTS: One isoform of immunoglobulin light chain spot was more frequently present in PF of infertile women than infertile patients. Nine protein spots had significantly higher expression in PF of infertile patients than infertile controls. They were 2 isoforms of serotransferrin, 1 isoform of complement C3, serum amyloid P-component, alpha-1-antitrypsin and clusterin; 3 protein spots remain unidentified. No protein spots had significantly lower expression in PF of infertile women with endometriosis than in PF of fertile controls. Complement C3 had higher PF levels in the luteal than in the follicular phase of the menstrual cycle in both infertile and fertile patients. CONCLUSION: Among women with endometriosis, those with infertility have aberrant expression of several PF proteins; most of these molecules are involved in the immune response.
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Cited by (24)
- Iron metabolism markers in peritoneal fluid of patients with endometriosis: systematic review and meta-analysis 2024
- Chronic Pelvic Pain, Vulvar Pain Disorders, and Proteomics Profiles: New Discoveries, New Hopes 2023
- Molecular biomarkers of endometriosis 2021
- Análise de marcadores protéicos no endométrio de mulheres portadoras de endometriose profunda intestinal 2019
- Proteomics Research and Its Possibility of Application in Endometriosis 2019
- OMICs Studies and Endometriosis Biomarker Identification 2017
- Analysis of Clusterin and Clusterin Receptors in the Endometrium and Clusterin Levels in Cervical Mucus of Endometriosis 2016
- Pituitary suppression before frozen embryo transfer is beneficial for patients suffering from idiopathic repeated implantation failure 2016
- The diagnosis of endometriosis with the help of mass spectrometry (a review) 2015
- A mass spectrometric insight into the origins of benign gynecological disorders 2015
- Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals 2014
- Understanding the pathogenesis of endometriosis through proteomics: Recent advances and future prospects 2013
- Proteomic analysis of eutopic and ectopic endometriotic tissues based on isobaric peptide tags for relative and absolute quantification (iTRAQ) method. 2013
- Diagnosis of Endometriosis: Proteomics 2011
- Non-invasive diagnosis of endometriosis with proteomic technologies 2011
- Physiologie péritonéale et fertilité 2011
- Urinary peptide profiling identifies a panel of putative biomarkers for diagnosing and staging endometriosis 2011
- Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis 2011
- Pathophysiology of Infertility in Endometriosis 2011
- Proteomics a Key Tool for a Better Understanding of Endometriosis: a Mini- Review 2011
- Haptoglobin concentration in peritoneal fluid of women with endometriosis 2010
- Molecular profiling of human endometrium and endometriosis 2010
- Proteomics and the search for biomarkers of female reproductive diseases 2010
- Polymorphism in Vitamin D-Binding Protein as a Genetic Risk Factor in the Pathogenesis of Endometriosis 2010
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