Immunoreactive endothelin-1 concentrations in follicular fluid of women with and without endometriosis undergoing in vitro fertilization-embryo transfer

M Abaé, Mick Abaé, Abaé M, M Glassberg, Glassberg M, Marilyn K. Glassberg, Mary H. Majercik, Majercik MH, M H Majercik, Hiroaki Yoshida, Yoshida H, H Yoshida, R Vestal, Ryan Vestal, Vestal R, David Puett, Puett D, D Puett
Fertility and sterility · 1994 · vol. 61(6) , pp. 1083–1087 · doi:10.1016/s0015-0282(16)56760-0 · PMID:8194621 · W2418594921
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This study measured endothelin-1 concentrations in follicular fluid from women undergoing IVF-ET to assess differences between those with and without endometriosis.

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Abstract

ObjectiveTo determine the concentrations of immunoreactive (IR) endothelin-1 in human follicular fluid (FF) and whether IR-endothelin-1 levels are different in women with endometriosis-associated infertility.DesignFollicular fluid and plasma samples, obtained from women with and without endometriosis undergoing IVF-ET, were collected at the time of oocyte aspiration and analyzed for IR-endothelin-1 levels.SettingInfertility clinic in an academic research environment.ResultsOverall, 90% of FF samples and 60% of plasma samples contained IR-endothelin-1 detectable above the threshold of assay sensitivity. Immunoreactive endothelin-1 levels (mean +/- SEM) in FF samples from women with and without endometriosis-associated infertility were 74 +/- 12 and 37 +/- 6 pg/mL, respectively. There was no difference in IR-endothelin-1 levels in FF samples between controlled ovarian hyperstimulation cycles with or without leuprolide acetate. No significant differences were detected in plasma IR-endothelin-1 levels in women with endometriosis-associated infertility when compared with those without.ConclusionsThese results demonstrate the presence of IR-endothelin-1 in human FF obtained at the time of oocyte aspiration for IVF-ET and higher levels of IR-endothelin-1 in FF of women with endometriosis-associated infertility.

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Condition tags

endometriosis

MeSH descriptors

Embryo Transfer Endometriosis Endothelins Endothelins Fertilization in Vitro Follicular Fluid Adult Chromatography, High Pressure Liquid Endometriosis Endometriosis Endothelins Endothelins Female Follicular Fluid Humans Infertility, Female Infertility, Female

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