MiR‐370‐3p inhibits the development of human endometriosis by downregulating EDN1 expression in endometrial stromal cells

Shun Zhou, Cheng-Yi Huang, Chengyi Huang, Wei Wang, Juan Liu
Cell biology international · 2021 · vol. 45(6) , pp. 1183–1190 · doi:10.1002/cbin.11552 · PMID:33470475 · W3125963944
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MiR-370-3p, downregulated in endometriosis patients, inhibits endometrial stromal cell proliferation and invasion by targeting EDN1 expression.

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Abstract

MiR-370-3p has been demonstrated to be downregulated in patients with endometriosis (EM). However, its role and molecular mechanisms in the progression of EM remain unclear. Real-time polymerase chain reaction was used to measure the expression of miR-370-3p and endothelin-1 (EDN1) in patients with or without EM. After miR-370-3p overexpression or knockdown in ectopic endometrial hEM15A cells, the changes in the proliferation, apoptosis, and migration and invasion capacities were detected by using cell counting kit-8, flow cytometry, and transwell methods. The interplay between miR-370-3p and EDN1 was confirmed by a luciferase reporter assay. Patients with EM showed adverse expression of EDN1 and miR-370-3p, especially in eutopic endometrium and ectopic endometrium. MiR-370-3p inhibited the proliferation, metastasis, and invasion capacities of hEM15A cells and promoted apoptosis. Investigation of its molecular mechanism revealed that miR-370-3p targeted EDN1 to influence the biological functions of hEM15A cells. MiR-370-3p represented as a therapeutic target for EM treatment.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Endometrium Endometrium Endothelin-1 MicroRNAs Stromal Cells Stromal Cells Stromal Cells Adolescent Adult Cells, Cultured Endometriosis Endothelin-1 Female Humans MicroRNAs Middle Aged Young Adult

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