Secretion of inhibin B during ovarian stimulation is decreased in infertile women with endometriosis

Anuja Dokras, Dokras A, A Dokras, Habana A, A Habana, Antonia Habana, Juan L. Giraldo, Giraldo J, J Giraldo, E Jones, Jones E, Ervin E. Jones
Fertility and Sterility · 2000 · vol. 74(1) , pp. 35–40 · doi:10.1016/s0015-0282(00)00568-9 · PMID:10899494 · W2107094752
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This study investigated inhibin B secretion during ovarian stimulation and found it was decreased in infertile women with endometriosis compared to controls.

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Abstract

Objective(s)To determine the levels and pattern of inhibin B secretion during ovarian stimulation in patients with endometriosis and to evaluate the correlation between inhibin B levels and variables of follicular and oocyte development.DesignRetrospective cohort study.SettingIVF center.Patient(s)Women with endometriosis (n = 20) and tubal factor (n = 10) as the only cause of infertility.Intervention(s)Inhibin B levels were measured during gonadotropin stimulation on day 1, days 8-11, day of hCG administration, and oocyte retrieval.Main outcome measure(s)Patterns and levels of inhibin B secretion were compared in the two groups. Other variables analyzed were age, days of gonadotropin stimulation and total ampules used, oocytes retrieved, and the fertilization and pregnancy rate.Result(s)Inhibin B levels and number of oocytes retrieved were significantly lower in patients with endometriosis than in the control group. Two patterns of inhibin B secretion were noted: It peaked in the midfollicular phase or on the day of hCG administration. In contrast, E2 levels peaked on the day of hCG administration. Inhibin B in the midfollicular phase in both groups correlated positively with number of oocytes retrieved. In addition, E2 and inhibin B levels in the midfollicular phase correlated positively.Conclusion(s)Decreased inhibin B secretion in patients with endometriosis suggests impaired granulosa cell function. Inhibin B may serve as an alternate marker to assess follicular development or to predict the number of oocytes retrieved.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Inhibins Ovulation Induction Adult Biomarkers Cohort Studies Endometriosis Endometriosis Estradiol Estradiol Female Granulosa Cells Granulosa Cells Humans Infertility, Female Infertility, Female Inhibins Pregnancy Retrospective Studies

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