Surgical removal of endometriomas adversely affects ovarian reserve: Comparison of serum FSH, AMH and AFC before and after cystectomy

Fatma Tanilir Çağiran, Zercan Kalı
In: Middle Black Sea Journal of Health Science · 2023 · vol. 9(3) , pp. 542–549 · doi:10.19127/mbsjohs.1266532 · W4385276575
article OA: diamond CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that endometrioma cystectomy significantly decreased serum AMH levels three months post-surgery but did not affect FSH or AFC values.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This study evaluated changes in ovarian reserve markers before and after endometrioma cystectomy in 14 symptomatic, normal-ovulatory women aged 21–36, measuring serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, and antral follicle count (AFC) preoperatively and 3 months post-surgery. Ovarian damage during surgery was reportedly minimized. The key finding was a significant reduction in serum AMH after cystectomy (3.21 ± 1.1 to 1.9 ± 0.6 ng/mL; p=0.02), while FSH and estradiol showed no significant change, and AFC did not differ significantly pre- versus postoperatively. The paper’s limitation is its small sample size and short follow-up period of only 3 months. This paper is centrally about endometriosis—specifically, how endometrioma cystectomy affects ovarian reserve biomarkers.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Objective: Surgical removal of endometriomas, even if performed in experienced hands, leads to a decrease in ovarian reserve in varying degrees depending on age. This study was designed to determine the pre- and post-surgical changes of ovarian reserve markers in patients who underwent endometrioma cystectomy. Methods: Gözde Akademi Hospital gynecology outpatient clinic with the diagnosis of symptomatic ovarian endometrioma was included in the study. Fourteen normal-ovulatory women aged between 21-36 were included in the study. In addition to serum anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), and estradiol levels, antral follicle count (AFC) was evaluated before and 3 months after cystectomy. Ovarian damage was avoided as much as possible during endometrioma surgery. Results: After endometrioma cystectomy, serum AMH levels were significantly decreased (3.21 ± 1.1 ng/mL vs 1.9 ± 0.6 ng/mL; p= 0.02). There was no significant change in serum FSH (5.97 ± 1.6 mIU/mL vs 7.34±0.55 mIU/mL, p=0.08) and estradiol (37.8 ±9.44 pg/mL vs 32.9 ±10.7 pg/mL, p=0.56) values measured three months after surgery. Similarly, there was no significant change in AFC values before and after surgery (4.12 ± 2.80 vs 4.89 ±3.06, p=0.24). Conclusion: Endometrioma cystectomy leads to a significant decrease in AMH levels, which is the main ovarian reserve marker, but does not affect AFC and FSH values.
Full text 1,820 characters · extracted from oa-html · 6 sections · click to expand

Abstract

Keywords Endometrioma, Kistektomi, AMH, FSH, Estradiol Surgical removal of endometriomas adversely affects ovarian reserve: Comparison of serum FSH, AMH and AFC before and after cystectomy

Abstract

Objective: Surgical removal of endometriomas, even if performed in experienced hands, leads to a decrease in ovarian reserve in varying degrees depending on age. This study was designed to determine the pre- and post-surgical changes of ovarian reserve markers in patients who underwent endometrioma cystectomy.

Methods

Gözde Akademi Hospital gynecology outpatient clinic with the diagnosis of symptomatic ovarian endometrioma was included in the study. Fourteen normal-ovulatory women aged between 21-36 were included in the study. In addition to serum anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), and estradiol levels, antral follicle count (AFC) was evaluated before and 3 months after cystectomy. Ovarian damage was avoided as much as possible during endometrioma surgery.

Results

After endometrioma cystectomy, serum AMH levels were significantly decreased (3.21 ± 1.1 ng/mL vs 1.9 ± 0.6 ng/mL; p= 0.02). There was no significant change in serum FSH (5.97 ± 1.6 mIU/mL vs 7.34±0.55 mIU/mL, p=0.08) and estradiol (37.8 ±9.44 pg/mL vs 32.9 ±10.7 pg/mL, p=0.56) values measured three months after surgery. Similarly, there was no significant change in AFC values before and after surgery (4.12 ± 2.80 vs 4.89 ±3.06, p=0.24).

Conclusion

Endometrioma cystectomy leads to a significant decrease in AMH levels, which is the main ovarian reserve marker, but does not affect AFC and FSH values.

Keywords

Endometrioma, Cystectomy, AMH, FSH, Estradiol

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometrioma

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK