Large ovarian endometriomas

J Donnez, Jacques Donnez, M Nisolle, Nadia Gillet, N Gillet, M Smets, Mireille Smets, S Bassil, F. Casanas‐Roux, F Casanas-Roux
Human Reproduction · 1996 · vol. 11(3) , pp. 641–645 · doi:10.1093/humrep/11.3.641 · PMID:8671283 · W1971732433
article OA: bronze CC0 ⤵ 298 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study describes a combined therapy of GnRHa and laser laparoscopy for large ovarian endometriomas, achieving 51% pregnancy and 8% recurrence.

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Abstract

The management of large endometriomas was described in a series of 814 patients. Combined therapy using gonadotrophin-releasing hormone agonist (GnRHa) and carbon dioxide laser laparoscopy was proposed. Drainage and GnRHa for 12 weeks provoked a reduction of the endometrioma size up to 50% of the initial value. After vaporization of the internal wall, a cumulative pregnancy of 51% after 1 year was achieved. A recurrence rate of 8% was observed for a follow-up of 2-11 years. Histological data demonstrated that the epithelium covering the ovary which is the mesothelium can invaginate in the ovarian cortex. Some of the invaginations were seen to be continuous with endometrial tissue, strongly suggesting the metaplasia theory in the pathogenesis of ovarian endometrioma.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Endometriosis Endometriosis Gonadotropin-Releasing Hormone Laser Therapy Ovarian Diseases Ovarian Diseases Combined Modality Therapy Endometriosis Endometriosis Female Gonadotropin-Releasing Hormone Goserelin Goserelin Humans Infertility, Female Infertility, Female Infertility, Female Infertility, Female Metaplasia Ovarian Cysts

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (50)

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