Contribution of diminished ovarian reserve to hypofertility associated with endometriosis.

Hock DL, D L Hock, Doreen L. Hock, Sharafi K, K Sharafi, Kiomars Sharafi, Dagostino L, L Dagostino, Lisa Dagostino, Kemmann E, E Kemmann, D B Seifer, Seifer DB, David B. Seifer
The Journal of reproductive medicine · 2001 · vol. 46(1) , pp. 7–10 · PMID:11209637 · W95555542
article OA: closed CC0 ⤵ 26 in-corpus citations
View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Women with stage III/IV endometriosis exhibit diminished ovarian reserve, evidenced by higher day 3 E2 and FSH levels compared to controls, unlike those with stage I/II disease.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: To determine if ovarian reserve, as measured by day 3 levels of E2 and FSH, was different in patients with endometriosis as compared to controls. STUDY DESIGN: Case-control study of 75 women with laparoscopically staged endometriosis and 75 age-matched controls undergoing in vitro fertilization/embryo transfer for male factor infertility. RESULTS: In women with stage III/IV endometriosis (revised American Fertility Society staging), day 3 E2 and FSH levels were significantly higher than control levels (51.9 pg/mL and 12.6 mIU/mL versus 34.7 pg/mL and 9.7 mIU/mL, P < .03). In contrast, women with stage I/II endometriosis did not differ significantly when compared to controls (36.8 pg/mL and 10.4 mIU/mL versus 34.0 pg/mL and 10.2 mIU/mL). The total group showed significantly higher E2 levels (41.8 pg/mL versus 34.1 pg/mL, P < .03), but no significant differences in FSH levels were observed. CONCLUSION: These data show that women with stage III/IV endometriosis have relatively diminished ovarian reserve, while this situation is not noted in women with stage I/II endometriosis. This observation is consistent with progressive loss of ovarian reserve in women with increasing stages of endometriosis independent of age.

My notes (saved in your browser only)

Outcome instruments

AFS

Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Ovary Case-Control Studies Embryo Transfer Endometriosis Endometriosis Endometriosis Estradiol Estradiol Female Fertilization in Vitro Follicle Stimulating Hormone Follicle Stimulating Hormone Humans Infertility, Female Infertility, Male Infertility, Male Male Ovary

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (26)

Source provenance

europepmc
last seen: 2026-09-26T06:15:21.694264+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:30.513821+00:00
License: CC0 · commercial use OK