Increased basal FSH levels as predictors of low‐quality follicles in infertile women with endometriosis

Bruno Ramalho de Carvalho, Ana Carolina Japur de Sá Rosa-e-Silva, Ana Carolina Japur de Sá Rosa e Silva, Júlio César Rosa-e-Silva, Júlio César Rosa e Silva, Rosana Maria dos Reis, Rui Alberto Ferriani, Marcos Felipe Silva de Sá, Marcos Felipe Silva-de-Sá
International Journal of Gynecology & Obstetrics · 2010 · vol. 110(3) , pp. 208–212 · doi:10.1016/j.ijgo.2010.03.033 · W2051205387
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Abstract

Abstract Objective To determine whether basal levels of follicle‐stimulating hormone (FSH) and anti‐müllerian hormone (AMH), antral follicle count (AFC), and the numbers of dominant follicles, oocytes, and mature oocytes retrieved after ovarian stimulation differed between infertile women with endometriosis and healthy women undergoing assisted reproduction techniques (ART). Method Of 77 consecutive ART candidates, 27 were infertile and had endometriosis. A male factor caused the infertility of the other 50, who acted as controls. Results The AMH and AFC levels were similar in the 2 groups. The FSH levels were higher (8.28 mIU/mL [range, 5.25–24.1 mIU/mL] vs 5.91 mIU/mL [range, 2.47–18.7 mIU/mL]; P < 0.01) in the study group. And the numbers of retrieved (n = 5 [range, 0–12] vs n = 9 [range, 0–27; P < 0.05) and mature oocytes (n = 4 [range, 0–11] vs n = 5 [range, 0–16]; P < 0.05) were less in the study group. Conclusion Because AMH levels were unchanged, endometriosis seems not to damage the primordial pool of follicles and oocytes, but to lessen the quality of the ovarian response to the hCG injection. Basal FSH levels may be of value in predicting ART success in women with the disease.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Follicle Stimulating Hormone Infertility, Female Ovarian Follicle Ovulation Induction Adult Anti-Mullerian Hormone Case-Control Studies Cell Count Endometriosis Endometriosis Endometriosis Female Follicle Stimulating Hormone Humans Infertility, Female Infertility, Female Infertility, Female Infertility, Female

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