Abbreviated endometriosis-associated infertility correlates with in vitro fertilization success

Ian S. Tummon, I S Tummon, Kimberly A. Colwell, K A Colwell, Catherine Jane MacKinnon, C J Mackinnon, J A Nisker, Jeffrey A. Nisker, A A Yuzpe, A. Albert Yuzpe
Journal of in vitro fertilization and embryo transfer : IVF · 1991 · vol. 8(3) , pp. 149–153 · doi:10.1007/bf01131705 · PMID:1919261 · W2093443581
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-12 ⓘ

This study reviewed 240 IVF cycles in couples with endometriosis as the sole cause of infertility, finding live birth rates were not reduced by advanced endometriosis and correlated positively with shorter infertility duration.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper reviewed a 6-year University Hospital London, Ontario experience of 240 IVF cycles in 124 couples where endometriosis was the only identified cause of infertility, using largely ultrasound-guided transvaginal oocyte retrieval with pregnancy follow-up. The study found that live birth rates were not reduced by more advanced degrees of endometriosis, while live births were positively correlated with a shorter duration of infertility. A key limitation is that the design is a retrospective review from a single center, which limits control over confounding and generalizability. This paper is centrally about endometriosis-associated infertility and reports how endometriosis severity and infertility duration correlate with IVF live-birth outcomes.

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Abstract

The utility of in vitro fertilization (IVF) for refractory infertility associated with endometriosis was studied by reviewing the 6-year experience with IVF and pregnancy follow-up at University Hospital, London, Ontario. Two hundred forty cycles were begun in 124 couples in whom endometriosis was the sole identified cause of infertility. In a program employing predominantly ultrasoundguided transvaginal oocyte retrieval, live birth rates were not reduced with advanced degrees of endometriosis. Live births were positively correlated with a shorter infertility duration. Similar content being viewed by others

References

Oehninger S., Acosta AA, Kreiner D, Muasher SJ Jones HW Jr, Rosenwaks Z: In vitro fertilization and embryo transfer (IVF/ET): an established and successful therapy for endometriosis. J Vitro Fert Embryo Transfer 1988;5:249–256 Yovich JL, Matson PL, Richardson PA, Hilliard C: Hormonal profiles and embryo quality in women with severe endometriosis treated by in vitro fertilization and embryo transfer. Fertil Steril 1988;50:308–313 Matson PL, Yovich JL: The treatment of infertility assocated with endometriosis by in vitro fertilization. Fertil Steril 1986;46:432–434 Wardle PG, Foster PA, Mitchell JD, McLaughlin EA, Sykes JAC, Corrigan E, Hull MGR, Ray BD, McDermott A: Endometriosis and IVF: Effect of prior therapy. Lancet 1986; 1:267–276 Damewood MD: The role of the new reproductive technologies including IVF and GIFT in endometriosis. Obstet Gynecol Clin North Am 1989;16:179–191 The American Fertility Society: Revised American Fertility Society Classification of Endometriosis: Fertil Steril 1985; 43:351 Small DRJ, Collins JA, Wilson EH, Wrixon W: Interpretation of semen analysis among infertile couples. Can Med Assoc J 1987;136:829–833 Yuzpe AA, Brown SE, Casper RF, Nisker JE, Graves G: Rates and outcomes of pregnancies achieved in the first 4 years of an in-vitro fertilization program. Can Med Assoc J 1989;140:167–172 Yuzpe AA, Brown SE, Casper RF, Nisker J, Graves G, Shatford L: Transvaginal, ultrasound-guided oocyte retrieval for in vitro fertilization. J Reprod Med 1989;34:937 Caro CM, Trounson A: Successful fertilization, embryo development, and pregnancy in human in vitro fertilization (IVF) using a chemically defined culture medium containing no protein. J Vitro Fert Embryo Transfer 1986;3:215 Molloy D, Martin M, Speirs A, Lopata A, Clarke G, McBain J, Ngu A, Johnston IH: Performance of patients with a “frozen pelvis” in an in vitro fertilization program. Fertil Steril 1987;47:450–455 Chillik CF, Acosta AA, Garcia JE, Perera S, Van Uem JFHM, Rosenwaks Z, Jones HW Jr: The role of in vitro fertilization in infertile patients with endometriosis. Fertil Steril 1985;44:56–61 Thomas EJ, Cooke ID: Successful treatment of asymptomatic endometriosis: Does it benefit infertile women? Br Med J 1987;294:1117–1119 Collins JA, Wrixon W, Janes LB, Wilson EH: Treatment-independent pregnancy among infertile couples. N Engl J Med 1983;309:1201–1206 Author information Authors and Affiliations Rights and permissions About this article Cite this article Tummon, I.S., Colwell, K.A., Mackinnon, C.J. et al. Abbreviated endometriosis-associated infertility correlates with in vitro fertilization success. J Assist Reprod Genet 8, 149–153 (1991). https://doi.org/10.1007/BF01131705 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/BF01131705

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fertilization in Vitro Infertility, Female Adult Aging Aging Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female Pregnancy Pregnancy Outcome

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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