Association between ovarian endometrioma and ovarian reserve

Michio Kitajima, Kitajima M, Khan KN, Khaleque Newaz Khan, Ayumi Harada, Harada A, Ken Taniguchi, Taniguchi K, Tsuneo Inoue, Inoue T, Masanori Kaneuchi, Kaneuchi M, Miura K, Kiyonori Miura, Masuzaki H, Hideaki Masuzaki
Frontiers in bioscience (Elite edition) · 2017 · vol. 10(1) , pp. 92–102 · doi:10.2741/e810 · PMID:28930606 · W2760433923
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper discusses how ovarian endometriomas and their surgical treatment can diminish ovarian reserve, impacting reproductive health in women with endometriosis and necessitating careful evaluation of ovarian reserve testing.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This review discusses the relationship between ovarian endometriomas and ovarian reserve, focusing on how endometriosis-associated infertility may involve diminished ovarian reserve, and how both endometriomas and cystectomy could contribute to reduced follicle number or quality. It describes proposed mechanisms including potential disruption of ovarian cortical histology that may affect primordial follicle dormancy, and notes that some patients experience poor ovarian response after surgery that can affect treatment outcomes. A key caveat emphasized is that ovarian reserve testing performed after surgery must be interpreted carefully with respect to the timing and the specific test selected, because such factors can influence results. This paper is centrally about endometriosis — specifically ovarian endometrioma’s association with ovarian reserve and related implications for endometriosis-associated infertility.

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Abstract

Endometrioma is one of the main pathologies of endometriosis, though its pathogenesis still remains enigmatic. Ovarian reserve is defined as the number and quality of the follicles left in the ovary at any given time. The cause of infertility in women with endometriosis is multifactorial. Diminished ovarian reserve is major concern in women with endometriosis-associated infertility. Cystectomy for endometriomas could negatively impact on post-operative ovarian reserve. Some women had surgery for endometriomas suffer from poor ovarian response, which directly affects treatment results. In addition, endometriomas themselves may be a cause of diminished ovarian reserve. Destruction of normal histological structure in ovarian cortex may affect dormancy of primordial follicles. Therefore, determination of ovarian reserve may serve as an important role in the management of reproductive health of women with endometriosis. Although the knowledge on the physiology of follicular development and mechanism of maintenance of ovarian reserve are rapidly accumulating, results obtained by ovarian reserve testing after surgery should be carefully evaluated according to the time-points and selected test. Further investigation on this issue is warranted.
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Abstract

Endometrioma is one of the main pathologies of endometriosis, though its pathogenesis still remains enigmatic. Ovarian reserve is defined as the number and quality of the follicles left in the ovary at any given time. The cause of infertility in women with endometriosis is multifactorial. Diminished ovarian reserve is major concern in women with endometriosis-associated infertility. Cystectomy for endometriomas could negatively impact on post-operative ovarian reserve. Some women had surgery for endometriomas suffer from poor ovarian response, which directly affects treatment results. In addition, endometriomas themselves may be a cause of diminished ovarian reserve. Destruction of normal histological structure in ovarian cortex may affect dormancy of primordial follicles. Therefore, determination of ovarian reserve may serve as an important role in the management of reproductive health of women with endometriosis. Although the knowledge on the physiology of follicular development and mechanism of maintenance of ovarian reserve are rapidly accumulating, results obtained by ovarian reserve testing after surgery should be carefully evaluated according to the time-points and selected test. Further investigation on this issue is warranted.

Keywords

- Ovarian Endometrioma - Ovarian Reserve - Surgery - Review

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Condition tags

endometriosisendometriomainfertility

MeSH descriptors

Endometriosis Ovarian Reserve Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Postoperative Period

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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