Influence of ovarian reserves on assisted reproductive and perinatal outcomes in patients with endometriosis: a retrospective study

Shuai Liu, Yaxin Guo, Fei Li, Lei Jin
Frontiers in endocrinology · 2023 · vol. 14 , pp. 1084927 · doi:10.3389/fendo.2023.1084927 · PMID:37251679 · PMC10213621 · W4378746262
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Endometriosis patients with normal or high ovarian reserves showed better reproductive outcomes but no increased risk of most adverse perinatal outcomes compared to those with diminished reserves.

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Abstract

OBJECTIVE: To investigate the association between different ovarian reserves and reproductive and adverse perinatal outcomes in patients with endometriosis. DESIGN: Retrospective study. SETTING: Reproductive Medicine Center in a hospital. PATIENTS: Patients surgically diagnosed with endometriosis were divided into three groups according to their ovarian reserve: diminished ovarian reserve (DOR) group (n=66), normal ovarian reserve (NOR) group (n=160), and high ovarian reserve (HOR) group (n=141). INTERVENTIONS: None. MAIN OUTCOME MEASURES: Live birth rate (LBR), cumulative live birth rate (CLBR), and adverse perinatal outcome for singleton live births. RESULTS: There were significantly higher live birth and cumulative live birth rates in endometriosis patients with NOR or HOR than in those with DOR. For adverse perinatal outcomes, patients with NOR or HOR had no significant association with preterm birth, gestational hypertension, placenta previa, fetal malformation, abruptio placentae, macrosomia, or low birth weight, except for a decreased risk of gestational diabetes mellitus. CONCLUSION: Our study revealed that although patients with endometriosis with NOR and HOR had increased reproductive outcomes, patients with endometriosis with DOR had still an acceptable live birth rate and a similar cumulative live birth rate with available oocytes. Moreover, patients with NOR and HOR might not exhibit a decreased risk of abnormal perinatal outcomes, except for gestational diabetes mellitus. Multicenter prospective studies are needed to further clarify the relationship.

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Condition tags

endometriosis

MeSH descriptors

Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational Diabetes, Gestational

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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