Role of biomarkers CA-125, CA-15.3 and CA-19.9 in the distinction between endometriomas and ovarian neoplasms

Jéssica de Souza Magalhães, Millena Prata Jammal, Paula Carolina Arvelos Crispim, Eddie Fernando Candido Murta, Eddie Fernando Cândido Murta, Rosekeila Simões Nomelini
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2021 · vol. 26(3) , pp. 268–274 · doi:10.1080/1354750x.2021.1885490 · PMID:33554683 · W3127247697
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

CA-19.9 and its combination with CA-125 effectively distinguish endometriomas from benign and malignant ovarian neoplasms.

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Abstract

PURPOSE: To evaluate the utilisation of CA-125, CA-15.3 and CA-19.9 in differentiating between ovarian neoplasms and endometriomas, and the best cut-off value for these tumour markers in this differentiation. MATERIALS AND METHODS: Preoperative serum values of CA-125, CA-15.3 and CA-19.9 were evaluated in 265 patients undergoing surgery for adnexal masses, being 32 non-neoplastic lesions, 134 benign neoplasms, 19 borderline tumours, 36 malignant neoplasms, and 44 endometriomas. ROC curves and Univariate and multivariate analyses were performed. RESULTS: Only CA-19.9 was useful in differentiating between endometriomas and ovarian neoplasms (benign and malignant tumours), being this marker found at higher levels in endometriomas. In multivariate analyses, CA-19.9 greater than 22.3 U/mL was considered an independent factor for the diagnosis of endometrioma, comparing endometrioma and ovarian cancer. Comparing endometrioma and all other groups, the clustering analysis using the combination CA-125 > 34.28 U/mL and CA-19.9 > 19.12 U/mL demonstrated that this association was considered an independent factor for the diagnosis of endometrioma. CONCLUSION: CA-9.9 is useful in distinguishing between endometriomas and ovarian cancer, and its combination with CA-125 is useful in differentiating endometrioma from other ovarian lesions.

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Condition tags

mesh:D004715endometrioma

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate CA-125 Antigen Endometriosis Membrane Proteins Mucin-1 Ovarian Neoplasms Adolescent Adult Aged Antigens, Tumor-Associated, Carbohydrate CA-125 Antigen Child Diagnosis, Differential Endometriosis Endometriosis Female Humans Membrane Proteins Middle Aged Mucin-1

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References (21)

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