Reactivity of CA19-9 and CA125 in histological subtypes of epithelial ovarian tumors and ovarian endometriosis.

Naohisa Nakagawa, Hiromi Koda, Noriko Nitta, Yukie Nakahara, Jiro Uno, Toru Hashimoto, Takashi Nakahori, Masaaki Hasegawa, Mikio Kataoka
In: Acta Medica Okayama · 2015 · vol. 69(4) , pp. 227–35 · doi:10.18926/amo/53559 · W1535784075
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Serum CA19-9 and CA125 levels differentiate ovarian endometriosis from serous adenocarcinoma and mucinous borderline tumors, suggesting CA19-9's potential as a biomarker for drug susceptibility.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This study evaluated whether preoperative serum carbohydrate antigen 19-9 (CA19-9) and CA125 levels could distinguish ovarian endometriosis (OE) from epithelial ovarian tumors (EOT) across histological subtypes and stages. The authors analyzed preoperative serum CA19-9 and CA125 in 195 histopathologically diagnosed OE or EOT patients, then conducted a case-control analysis including 113 healthy controls. They found CA19-9 and CA125 were useful for differentiating OE from serous adenocarcinoma, but not for separating OE from other EOT; CA19-9 was also useful for distinguishing OE from stage I mucinous borderline ovarian tumors, with performance related to interstitial leukocyte infiltration. The paper’s caveat is that marker utility was limited to specific comparisons rather than broadly discriminating all OE versus EOT subtypes. This paper is centrally about endometriosis — it specifically tests serum CA19-9 and CA125 reactivity to differentiate ovarian endometriosis from epithelial ovarian tumor subtypes.

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Abstract

Previous reports have shown that some ovarian endometrioid adenocarcinomas and ovarian clear cell adenocarcinomas derive from ovarian endometriosis (OE), and that endocervical-like mucinous borderline ovarian tumors are associated with OE. We examined the relationship between the staging and histological subtypes of OE or epithelial ovarian tumors (EOT) and the serum levels of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) to evaluate the potential of these markers for preoperative diagnosis. First, we analyzed the preoperative serum levels of CA19-9 and CA125 in 195 patients who were histopathologically diagnosed with OE or EOT. We then performed a case-control study in which 308 women were enrolled, the 195 women described above and 113 healthy women as control subjects. Serum CA19-9 and CA125 levels were found to be useful in differentiating between OE and serous adenocarcinoma, but not between OE and other EOT. Moreover, serum CA19-9 levels were useful for preoperative assessment between OE and stage I mucinous borderline ovarian tumors, with or without the interstitial infiltration. In addition, considering that the serum CA19-9 levels in stage I mucinous borderline ovarian tumors were elevated via the interstitial infiltration of leukocytes and that precancerous lesions are associated with a cancerous glycosylation disorder in the process of inflammatory carcinogenesis, the CA19-9 level may be considered a suitable biomarker for estimating drug susceptibility.
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| ID | 53559 | | JaLCDOI | | | FullText URL | | | Author | Nakagawa, Naohisa Koda, Hiromi Nitta, Noriko Nakahara, Yukie Uno, Jiro Hashimoto, Toru Nakahori, Takashi Hasegawa, Masaaki Kataoka, Mikio | | Abstract | Previous reports have shown that some ovarian endometrioid adenocarcinomas and ovarian clear cell adenocarcinomas derive from ovarian endometriosis (OE), and that endocervical-like mucinous borderline ovarian tumors are associated with OE. We examined the relationship between the staging and histological subtypes of OE or epithelial ovarian tumors (EOT) and the serum levels of carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 125 (CA125) to evaluate the potential of these markers for preoperative diagnosis. First, we analyzed the preoperative serum levels of CA19-9 and CA125 in 195 patients who were histopathologically diagnosed with OE or EOT. We then performed a case-control study in which 308 women were enrolled, the 195 women described above and 113 healthy women as control subjects. Serum CA19-9 and CA125 levels were found to be useful in differentiating between OE and serous adenocarcinoma, but not between OE and other EOT. Moreover, serum CA19-9 levels were useful for preoperative assessment between OE and stage I mucinous borderline ovarian tumors, with or without the interstitial infiltration. In addition, considering that the serum CA19-9 levels in stage I mucinous borderline ovarian tumors were elevated via the interstitial infiltration of leukocytes and that precancerous lesions are associated with a cancerous glycosylation disorder in the process of inflammatory carcinogenesis, the CA19-9 level may be considered a suitable biomarker for estimating drug susceptibility. | | Keywords | ovarian endometriosis epithelial ovarian tumors histological subtype carbohydrate antigen 19-9 carbohydrate antigen 125 | | Amo Type | Original Article | | Publication Title | Acta Medica Okayama | | Published Date | 2015-08 | | Volume | volume69 | | Issue | issue4 | | Publisher | Okayama University Medical School | | Start Page | 227 | | End Page | 235 | | ISSN | 0386-300X | | NCID | AA00508441 | | Content Type | Journal Article | | language | English | | Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School | | File Version | publisher | | Refereed | True | | PubMed ID | | | Web of Science KeyUT |

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