Postoperative Pregnancy Outcomes Following Laparoscopic Surgical Management in Women with Stage III/IV Endometriosis: A Single-Center Follow-Up Study

Maya Fujii, Akemi Koshiba, Fumitake Ito, Izumi Kusuki, Jo Kitawaki, Taisuke Mori
Gynecology and minimally invasive therapy · 2023 · vol. 12(3) , pp. 153–160 · doi:10.4103/gmit.gmit_132_22 · PMID:37807984 · W4380681491
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Laparoscopic surgery for stage III/IV endometriosis yielded a 76.1% postoperative pregnancy rate, with the endometriosis fertility index significantly predicting pregnancy outcomes.

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Abstract

Objectives: The effects of laparoscopic surgical management in women with stage III/IV endometriosis remain controversial. The standard extent of resection for stage III/IV endometriosis with deep endometriosis to treat endometriosis-associated infertility is debatable. This study aimed to assess the postoperative pregnancy outcomes following a routine surgical intervention for stage III/IV endometriosis patients. Materials and Methods: Patients with stage III/IV endometriosis who underwent conservative laparoscopic surgery at our hospital between January 2010 and December 2018 were retrospectively analyzed. Statistical analyses were performed to determine the correlations between endometriosis features and postoperative pregnancy outcomes. Results: Of 256 patients enrolled, 94 wished to conceive. Exclusion criteria: ≥40 years, adenomyosis, partners with infertility issues. Finally, 71 women were included. The overall postoperative pregnancy rate was 76.1% ( n = 54): 49 and five from non-assisted reproductive technology (ART) and ART, respectively. The postoperative pregnancy rate in patients diagnosed with infertility presurgery (40/71) was 70.0% ( n = 28): 24 (non-ART) and four (ART). The endometriosis fertility index (EFI) score was higher in the pregnant than in the nonpregnant group ( P = 0.03). The EFI score and surgical score of EFI were higher in the non-ART than in the ART group ( P = 0.04; P = 0.02); in the infertile group, they were higher in the pregnant than in the nonpregnant group ( P = 0.018; P = 0.027). Conclusion: Our postoperative pregnancy rate after conservative laparoscopic surgery for patients with stage III/IV endometriosis compared favorably with previous reports. EFI was a significant predictor of postoperative pregnancy. Our surgical approach to maintain a high surgical score of EFI might help treat endometriosis-associated infertility.

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endometriosisadenomyosisinfertility

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