Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study

Wiweko B, Budi Wiweko, Quamila Fahrizani Afdi, Afdi QF, Achmad Kemal Harzif, Gita Pratama, Sumapradja K, Kanadi Sumapradja, Muharam R, Raden Muharam, Hestiantoro A, Andon Hestiantoro, Sarah Chairani Zakirah, Zakirah SC
International journal of reproductive biomedicine · 2020 · vol. 18(12) , pp. 1065–1072 · doi:10.18502/ijrm.v18i12.8028 · PMID:33426417 · PMC7778751 · W3114899515
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This study found that age was the only significant predictor of ovarian response in poor responders to in vitro fertilization, while BMI, endometriosis, and ovarian surgery history affected Poseidon group classifications.

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This cross-sectional study analyzed factors associated with ovarian reserve among women categorized as poor responders to in vitro fertilization, using clinical and reproductive variables reported for that group. The key finding was an association between ovarian reserve measures and specific patient factors examined in the analysis, identifying which characteristics were most closely linked with reduced ovarian reserve in poor responders. A major limitation is that the cross-sectional design cannot establish causal relationships between the identified factors and ovarian reserve. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Background: Poor ovarian reserve and a high rate of pregnancy failure associated with low quality and quantity of oocytes are observed in poor responders to in vitro fertilization. Objective: To assess the effect of age, body mass index (BMI), endometriosis, and history of ovarian surgery on ovarian reserve in a group of poor responders. Materials and Methods: In this cross-sectional study 749 women who referred to Yasmin Clinic of Dr Cipto Mangunkusumo National General Hospital from January 2013 to June 2017 were enrolled. Two definitions of poor responders and Poseidon criteria and consecutive sampling techniques were used. Participants were divided into good and poor responder groups based on the ovarian reserve test; participant with oocyte ≤ 3 was classified as a poor responder. Based on this, 188 participants with nine (4-47) oocytes were included in the poor responder group. While good responder comprised of two (0-3) oocytes. Results: Age and anti-Mullerian hormone level (AMH) were significantly associated with ovarian reserve in the poor-responder group (p < 0.001). However, in multivariate analyses, age was the only significant predictor of ovarian response in the poor responder group (p = 0.004). While endometriosis was the significant predictor of Poseidon groups 1 and 4, surgical history was the significant predictor of Poseidon groups 2 and 3. Meanwhile, an increase in BMI decreased the risk of classification under Poseidon group 3. Conclusion: Age, AMH, BMI, endometriosis, and history of ovarian surgery affected the risk of classification of the Poseidon group. Key words: Ovarian reserve, Poseidon, In vitro fertilization.
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Publication International Journal of Reproductive BioMedicine (IJRM) Record type Journal article Published 21 December 2020 Authors Budi Wiweko | Quamila Fahrizani Afdi | Achmad Kemal Harzif | Gita Pratama | Kanadi Sumapradja | Raden Muharam | Andon Hestiantoro | Sarah Chairani Zakirah The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ijrm.v18i12.8028', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'International Journal of Reproductive BioMedicine (IJRM)', 'primary-resource': 'https://knepublishing.com/index.php/ijrm/article/view/8028', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'http://journals.ssu.ac.ir/ijrmnew/article-1-1607-en.html', 'tld': 'ssu.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}, {'url': 'https://knepublishing.com/index.php/ijrm/article/view/8028', 'tld': 'knepublishing.com', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '21 December 2020', 'publication': 'International Journal of Reproductive BioMedicine (IJRM)', 'title': 'Analysis of factors associated with ovarian reserve in a group of poor responders to in vitro fertilization: A cross-sectional study', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ijrm.v18i12.8028', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Budi Wiweko | Quamila Fahrizani Afdi | Achmad Kemal Harzif | Gita Pratama | Kanadi Sumapradja | Raden Muharam | Andon Hestiantoro | Sarah Chairani Zakirah', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ijrm.v18i12.8028 JSON XML

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