Reproductive disorders affecting fertility in endometriosis

Brosens I, Ivo Brosens, Campo R, Rudi Campo, Gordts S, Stephan Gordts
Reproductive BioMedicine Online · 2002 · vol. 4 , pp. 59–63 · doi:10.1016/s1472-6483(12)60119-9 · PMID:12470568 · W1966923533
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This paper reviews reproductive disorders that impact fertility in women diagnosed with endometriosis.

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Abstract

The classical concept of endometriosis as a cause of infertility is challenged. Traditionally, both surgical and medical therapy of endometriosis-associated infertility has focused on eliminating or reducing the visible implants. The classic 6-month medical approach has been a failure, and surgery may moderately enhance fertility, but its benefit in the absence of adhesions is still doubtful. Recent studies have shown that endometriosis is characterized by an aberrant response to sex steroid hormones, resulting in pleiotropic dysfunctions of the reproductive system involving the uterine, peritoneal and ovarian micro-environment. Studies on endometriosis and IVF have been highly relevant in revealing the pleiotropic dysfunctions in patients with endometriosis, although the results should be interpreted with caution. The conclusion seems to support the view that infertility in patients with endometriosis is primarily dysfunctional, rather than lesional, in origin. It is concluded that the place of medical therapy in endometriosis should be reviewed and that the surgical approach needs to be complemented by appropriate medical therapy to restore fertility.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Infertility, Female Endometriosis Female Fertilization in Vitro Humans Infertility, Female Oocytes Oocytes Ovary Ovary Time Factors Tissue Adhesions Uterus Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (51)

Cited by (6)

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License: CC0 · commercial use OK