Integrin Adhesion Molecules in the Endometrial Glandular Epithelium in Patients with Endometriosis or Adenomyosis

Hirotaka Ota, H Ota, Toshinobu Tanaka, T Tanaka
Journal of Obstetrics and Gynaecology Research · 1997 · vol. 23(5) , pp. 485–491 · doi:10.1111/j.1447-0756.1997.tb00877.x · PMID:9392916 · W2055344541
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This study found increased expression of specific beta 1-integrins and E-cadherin in eutopic endometrial glands of patients with endometriosis and adenomyosis compared to controls.

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Abstract

OBJECTIVE: To assess the role of beta 1-integrin and E-cadherin molecules in the eutopic glandular epithelium in patients with endometriosis or adenomyosis. STUDY DESIGN: Twenty-four patients with endometriosis, and 22 patients with adenomyosis diagnosed histologically were selected as subjects. The controls consisted of 29 fertile women. Eutopic endometria were obtained by curettage or immediately after the operation. The samples were immunohistochemically examined for the expression of very late activation antigen-2 (VLA-2), VLA-3, VLA-4, VLA-5, VLA-6, and E-cadherin. RESULTS: The expression of each VLA molecule and E-cadherin except VLA-4, VLA-5, and VLA-6 was significantly increased throughout the menstrual cycle in endometria in both the endometriosis and adenomyosis groups. In contrast, the expression of VLA-4 in the adenomyosis group was significantly reduced in the secretory phase. CONCLUSION: Altered expression of beta 1-integrins and E-cadherin was observed throughout the menstrual cycle in patients with endometriosis and adenomyosis, suggesting the defective microenvironment of the endometrium.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Cadherins Endometriosis Endometrium Integrin beta1 Integrins Adult Animals Antibodies, Monoclonal Cadherins Cadherins Endometriosis Endometriosis Endometrium Endometrium Epithelium Epithelium Epithelium Female Humans Immunohistochemistry

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