Luteinizing hormone receptor disorder in endometriosis

L Rönnberg, Rönnberg L, Lars Rönnberg, Kauppila A, Antti Kauppila, A Kauppila, H Rajaniemi, Rajaniemi H, Hannu Rajaniemi
Fertility and Sterility · 1984 · vol. 42(1) , pp. 64–68 · doi:10.1016/s0015-0282(16)47959-8 · PMID:6327403 · W2419326061
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This paper investigates the role of the luteinizing hormone receptor in the development and progression of endometriosis.

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Abstract

Luteinizing hormone (LH) receptor concentrations in ovarian follicles and corpora lutea were measured in 51 patients with histologically proven endometriosis and in 41 control patients. The LH receptor concentrations in cases of endometriosis were lower during the early (0.43 +/- 0.11 [mean +/- standard error] versus 1.31 +/- 0.27 fmol/mg protein; P less than 0.001) and late (0.48 +/- 0.10 versus 1.59 +/- 0.22 fmol/mg protein; P less than 0.001) follicular phase, and during the late luteal phase (2.62 +/- 0.55 versus 4.62 +/- 0.65 fmol/mg protein; P less than 0.05) of the cycle than in control patients. In contrast to the control patients, the LH receptor concentration during the follicular phase remained constant in endometriosis, being lower in patients with extensive or severe disease than in patients with moderate or mild disease (0.28 +/- 0.07 versus 0.61 +/- 0.21 fmol/mg protein; P less than 0.05). Endometriosis-associated infertility might be a consequence of a defect in the mechanism mediating LH action in the ovaries.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Neoplasms Receptors, Cell Surface Adult Corpus Luteum Corpus Luteum Corpus Luteum Endometriosis Female Humans Menstruation Middle Aged Ovarian Follicle Ovarian Follicle Ovarian Follicle Ovarian Neoplasms Receptors, Cell Surface Receptors, Cell Surface Receptors, LH

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (34)

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