The effect of serum obtained before and after treatment for endometriosis on in vitro development of two-cell mouse embryos

Abu-Musa A, A Abu-Musa, Antoine Abu‐Musa, Takahashi K, Kentaro Takahashi, K. Takahashi, Manabu Kitao, M Kitao, Kitao M
Fertility and sterility · 1992 · vol. 57(5) , pp. 1098–1102 · doi:10.1016/s0015-0282(16)55030-4 · PMID:1572479 · W2337836606
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This study investigated the impact of serum from endometriosis patients, collected before and after treatment, on the in vitro development of two-cell mouse embryos.

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Abstract

ObjectiveTo evaluate the effect of serum obtained before and after treatment for endometriosis on in vitro development of two-cell mouse embryos.DesignPretreatment and post-treatment comparison of mouse embryo development in serum supplements from patients with endometriosis; results were compared using chi 2 analysis.SettingInfertility Clinic, Shimane Medical University, Izumo, Japan.PatientsTen consecutive women with endometriosis who underwent treatment for the disease. Seven women who were managed expectantly served as controls.InterventionsAll patients underwent laparoscopic or conservative surgery. This was followed by a 6-month course of either danazol 400 mg/d (6 patients) or buserelin acetate 900 micrograms/d (4 patients).Main outcome measure(s)Total number of embryos that reached blastocyst stage after 72 hours of incubation were compared before and after treatment.ResultsBefore treatment, 23% of the embryos reached blastocyst stage, whereas 8 of the 10 serum samples were embryo toxic. After treatment, significantly more embryos (59%) developed to blastocysts, and only one serum sample remained embryo toxic. In the control group, there was no significant difference in the number of embryos that reached blastocyst stage after expectant treatment.ConclusionThe embryo toxicity of serum samples from patients with endometriosis is lost after treatment.

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Condition tags

endometriosis

MeSH descriptors

Embryonic and Fetal Development Endometriosis Animals Culture Techniques Endometriosis Endometriosis Female Humans Mice Mice Mice, Inbred ICR

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