Effect of serum from fertile and infertile patients with endometriosis on the development of mouse embryos
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Serum from infertile patients with endometriosis was found to be toxic to mouse embryo development, unlike serum from fertile patients with the disease.
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Abstract
OBJECTIVE: To evaluate the effect of serum from infertile and fertile patients with endometriosis on the development of 2-cell mouse embryos. PATIENTS: Serum was obtained from 26 infertile patients and 8 fertile patients with endometriosis. Mouse embryo development in serum samples was compared using chi 2 analysis. RESULTS: In the infertile group 23% of the embryos reached blastocyst stage, whereas 22 of the 26 samples were embryo toxic. In the fertile group significantly more embryos (45%) developed to blastocysts and only one serum samples was embryo toxic. CONCLUSION: The embryo toxicity of serum samples from patients with endometriosis is related to the infertility associated with the disease and not with the disease per se.
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:11:02.671803+00:00
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