Effect of Serum from Patients with Endometriosis on the Development of Mouse Embryos

Abu-Musa A, A Abu-Musa, Antoie Abu-Musa, Takahashi K, Kentaro Takahashi, K Takahashi, Manabu Kitao, M Kitao, Kitao M
Gynecologic and obstetric investigation · 2010 · vol. 33(3) , pp. 157–160 · doi:10.1159/000294871 · PMID:1612528 · W1995711982
article OA: closed CC0 ⤵ 6 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-14 ⓘ

Serum from endometriosis patients significantly reduced mouse embryo development to the blastocyst stage compared to control groups, suggesting the presence of embryonic toxic factors.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The effect of serum from patients with endometriosis on the in vitro development of 2-cell mouse embryos was evaluated in the present study. Embryos were cultured for 72 h in 5% serum supplement from patients with endometriosis, infertile patients with no evidence of endometriosis, and Ham's F-10 medium with no serum supplement. Significantly less embryos developed to the blastocyst stage at 72 h in the endometriosis group as compared with the nonendometriosis groups and Ham's F-10 medium (p less than 0.05). These results suggest the presence of one or more serum factors that are toxic to early embryonic development and thus may play a role in the infertility associated with endometriosis, especially with respect to early embryonic loss.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Embryonic and Fetal Development Endometriosis Animals Blastocyst Culture Media Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Infertility, Female Menstrual Cycle Mice Mice, Inbred ICR

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (6)

Source provenance

europepmc
last seen: 2026-07-27T06:15:28.040536+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:54.876058+00:00
License: CC0 · commercial use OK