Effect of serum from patients with endometriosis on the development of mouse embryos
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⤵ 6 in-corpus citations
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Serum from endometriosis patients significantly reduced mouse embryo development to the blastocyst stage compared to control groups, suggesting the presence of embryonic toxic factors.
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Abstract
The effect of serum from patients with endometriosis on the in vitro development of 2-cell mouse embryos was evaluated in the present study. Embryos were cultured for 72 h in 5% serum supplement from patients with endometriosis, infertile patients with no evidence of endometriosis, and Ham's F-10 medium with no serum supplement. Significantly less embryos developed to the blastocyst stage at 72 h in the endometriosis group as compared with the nonendometriosis groups and Ham's F-10 medium (p less than 0.05). These results suggest the presence of one or more serum factors that are toxic to early embryonic development and thus may play a role in the infertility associated with endometriosis, especially with respect to early embryonic loss.
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Cited by (6)
- Endometriosis Is a Cause of Infertility. Does Reactive Oxygen Damage to Gametes and Embryos Play a Key Role in the Pathogenesis of Infertility Caused by Endometriosis? 2018
- Cellular and molecular basis for endometriosis-associated infertility 2012
- Effect of serum from fertile and infertile patients with endometriosis on the development of mouse embryos 1996
- Evaluation of serum-associated embryotoxicity in women with reproductive disorders 1995
- The effect of serum from infertile women with endometriosis on fertilization and early embryonic development in a murine in vitro fertilization model 1995
- The effect of serum obtained before and after treatment for endometriosis on in vitro development of two-cell mouse embryos 1992
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- europepmc
- last seen: 2026-10-19T06:17:24.038039+00:00
- openalex
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- pubmed
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- unpaywall
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