The effect of serum from infertile women with endometriosis on fertilization and early embryonic development in a murine in vitro fertilization model

Kathleen A. Miller, Miller KA, K A Miller, Pittaway DE, D E Pittaway, Donald E. Pittaway, J L Deaton, Jeffrey L. Deaton, Deaton JL
Fertility and sterility · 1995 · vol. 64(3) , pp. 623–626 · doi:10.1016/s0015-0282(16)57802-9 · PMID:7641919 · W2345307970
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This study investigated how serum from infertile women with endometriosis affects fertilization and early embryonic development in a murine in vitro fertilization model.

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Abstract

ObjectiveTo evaluate the effect of serum from infertile women with endometriosis on fertilization and embryonic development in a murine IVF model.DesignPretreatment and post-treatment comparison of murine oocyte fertilization and early embryonic development with the addition of serum supplements from infertile women with endometriosis.SettingTertiary care academic medical center.PatientsSera from 10 fertile women without endometriosis and 28 infertile women with endometriosis both before and after laser laparoscopy.ResultsWhen compared with serum from fertile women, serum from infertile women with endometriosis inhibited fertilization rates (51% versus 81%) and subsequent embryonic development rates (46% versus 79%). The inhibitory effect was greater as the stage of endometriosis increased. Treatment of endometriosis by laser laparoscopy improved both fertilization (51% versus 56%) and early embryonic development rates (46% versus 58%).ConclusionsSerum from infertile women with endometriosis inhibits both fertilization and early embryonic development in the murine IVF model. Inhibition of fertilization and early embryonic development rates increases as the stage of endometriosis increases. Improved fertilization and early embryonic development rates are observed after treatment of endometriosis by laser laparoscopy.

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Condition tags

endometriosis

MeSH descriptors

Blood Embryonic and Fetal Development Endometriosis Fertilization in Vitro Infertility, Female Adolescent Adult Animals Endometriosis Endometriosis Endometriosis Female Humans Infertility, Female Infertility, Female Laparoscopy Laser Therapy Mice

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