Immunoreactive endothelin-1 concentrations in follicular fluid of women with and without endometriosis undergoing in vitro fertilization-embryo transfer

M Abaé, Mick Abaé, Abaé M, M Glassberg, Glassberg M, Marilyn K. Glassberg, Mary H. Majercik, Majercik MH, M H Majercik, Hiroaki Yoshida, Yoshida H, H Yoshida, R Vestal, Ryan Vestal, Vestal R, David Puett, Puett D, D Puett
Fertility and sterility · 1994 · vol. 61(6) , pp. 1083–1087 · doi:10.1016/s0015-0282(16)56760-0 · PMID:8194621 · W2418594921
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This study measured endothelin-1 concentrations in follicular fluid from women undergoing IVF-ET to assess differences between those with and without endometriosis.

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Abstract

OBJECTIVE: To determine the concentrations of immunoreactive (IR) endothelin-1 in human follicular fluid (FF) and whether IR-endothelin-1 levels are different in women with endometriosis-associated infertility. DESIGN: Follicular fluid and plasma samples, obtained from women with and without endometriosis undergoing IVF-ET, were collected at the time of oocyte aspiration and analyzed for IR-endothelin-1 levels. SETTING: Infertility clinic in an academic research environment. RESULTS: Overall, 90% of FF samples and 60% of plasma samples contained IR-endothelin-1 detectable above the threshold of assay sensitivity. Immunoreactive endothelin-1 levels (mean +/- SEM) in FF samples from women with and without endometriosis-associated infertility were 74 +/- 12 and 37 +/- 6 pg/mL, respectively. There was no difference in IR-endothelin-1 levels in FF samples between controlled ovarian hyperstimulation cycles with or without leuprolide acetate. No significant differences were detected in plasma IR-endothelin-1 levels in women with endometriosis-associated infertility when compared with those without. CONCLUSIONS: These results demonstrate the presence of IR-endothelin-1 in human FF obtained at the time of oocyte aspiration for IVF-ET and higher levels of IR-endothelin-1 in FF of women with endometriosis-associated infertility.

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Condition tags

endometriosis

MeSH descriptors

Embryo Transfer Embryo Transfer Endometriosis Endothelins Endothelins Fertilization in Vitro Fertilization in Vitro Follicular Fluid Adult Adult Chromatography, High Pressure Liquid Chromatography, High Pressure Liquid Endometriosis Endometriosis Endometriosis Endothelins Endothelins Endothelins Female Female

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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