Follicular fluid of women with endometriosis stimulates the proliferation of endometrial stromal cells
article
OA: bronze
CC0
⤵ 29 in-corpus citations
AI-generated summary
Follicular fluid from women with endometriosis significantly increased endometrial stromal cell proliferation compared to fluid from women without the condition.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
The peritoneal environment in endometriosis is known to have growth-promoting effects on endometrial cells. To investigate whether follicular fluid, a contributor to the peritoneal fluid, stimulates endometrial cell proliferation, we incubated endometrial stromal cells in culture with various dilutions of follicular fluid obtained from women with or without endometriosis undergoing oocyte retrieval for in-vitro fertilization. Cell proliferation assays were performed using follicular fluid from 28 women (without endometriosis, n = 13; with endometriosis, n = 15) in eight different endometrial stromal cell culture set-ups. Cell proliferation was assessed by a colorimetric method. Maximum cell proliferation was detected when endometrial cells were incubated with 50% dilution of follicular fluid for 48 h. Follicular fluid from women with endometriosis induced significantly higher cell proliferation than follicular fluid from women without endometriosis (P < 0.05). Our findings indicate that follicular fluid contents may contribute to the growth-promoting factors in the peritoneal fluid of women with endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (20)
- Characterization of human purified epithelial and stromal cells from endometrium and endometriosis in tissue culture via openalex
- Cyclic changes of peritoneal fluid parameters in normal and infertile patients. via openalex
- Effect of Peritoneal Fluid From Endometriosis Patients on Endometrial Stromal Cell Proliferation In Vitro via openalex
- Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women via openalex
- Immunoreactive endothelin-1 concentrations in follicular fluid of women with and without endometriosis undergoing in vitro fertilization-embryo transfer via openalex
- In vitro culture of endometrial stromal and gland cells as a model for endometriosis: The effect of peritoneal fluid on proliferation via openalex
- Retrograde menstruation in healthy women and in patients with endometriosis. via openalex
- The insulin-like growth factor system in human peritoneal fluid: its effects on endometrial stromal cells and its potential relevance to endometriosis. via openalex
- The peritoneal environment in endometriosis via openalex
- W1982774184 via openalex
- W2057769061 via openalex
- W2072979627 via openalex
- W2084405521 via openalex
- W2114918609 via openalex
- W2163436394 via openalex
- W2395252434 via openalex
- W2015629565 via openalex
- W2477008945 via openalex
- W2026789899 via openalex
- W1989383031 via openalex
Cited by (29)
- The cytokine profiles in follicular fluid and reproductive outcomes in women with endometriosis 2022
- Endometriosis and ovarian dysfunction 2021
- Monocyte chemotactic protein-1 concentrations and expression of women with endometriosis undergoing IVF cycles 2021
- Metabolomics in endometriosis: challenges and perspectives for future studies 2021
- The role of unfolded protein response in the pathogenesis of endometriosis: contribution of peritoneal fluid 2020
- Diagnosis Of Endometriosis In The Light Of Prevalent Theories 2019
- Is there an immune modulating role for follicular fluid in endometriosis? A narrative review 2019
- Effect of bone marrow mesenchymal stem cells transplantation on BMP-15 expression and Graafian follicle count in mice model of endometriosis 2019
- Molecular and Cellular Pathogenesis of Endometriosis 2017
- Oxidative Stress Statues in Serum and Follicular Fluid of Women with Endometriosis. 2017
- Iron availability is increased in individual human ovarian follicles in close proximity to an endometrioma compared with distal ones 2014
- Endometriosis May Be Promoted by Midkine: Possible Involvement of Ovarian Follicles 2012
- Cellular and molecular basis for endometriosis-associated infertility 2012
- Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis 2011
- Paracrine regulation of endometriotic tissue 2007
- Mitochondrial gene expression in granulosa cells of severe endometriosis with in vitro fertilization and embryo transfer 2007
- Increased ENA‐78 in the follicular fluid of patients with endometriosis 2006
- Lateral distribution of endometriomas as a function of age 2006
- Endometriosis: epidemiology and aetiological factors 2004
- Does previous surgery influence the asymmetric distribution of endometriotic lesions? 2004
- Endometriosis: epidemiology and aetiological factors 2004
- Endometriosis and Inflammation in Infertility 2004
- Endometriosis: novel etiopathogenetic concepts and clinical perspectives 2002
- New advances in the understanding of endometriosis related infertility 2002
- Influence of severe endometriosis on gene expression of vascular endothelial growth factor and interleukin-6 in granulosa cells from patients undergoing controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer 2002
- Theories of endometriosis 2001
- Follicular fluid as a favourable environment for endometrial and endometriotic cell growth in vitro 2001
- Follicular hormonal environment and embryo quality in women with endometriosis 2000
- The relevance of the peritoneal fluid in endometriosis-associated infertility 1999
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:10:35.327253+00:00
License: CC0
· commercial use OK