Increased ENA‐78 in the follicular fluid of patients with endometriosis

Wunder DM, Dorothea M Wunder, Dorothea Wunder, Michael D. Mueller, Martin Birkhäuser, Birkhäuser MH, Martin H Birkhäuser, Nick A. Bersinger, Bersinger NA
Acta obstetricia et gynecologica Scandinavica · 2006 · vol. 85(3) , pp. 336–342 · doi:10.1080/00016340500501715 · PMID:16553183 · W2032321648
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Follicular fluid from endometriosis patients showed significantly higher levels of epithelial neutrophil-activating peptide 78, tumor necrosis factor-alpha, and interleukin-6 compared to controls.

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Abstract

BACKGROUND: It is known that endometriosis is an inflammatory disease and those patients seem to have lower pregnancy rates. The aim of the study was to investigate the concentrations of chemokines and proinflammatory cytokines in the follicular fluid of patients with and without endometriosis. METHODS: Follicular aspiration, recovering follicular fluid during assisted reproductive treatment, follicular fluid storage and analysis of chemokines and proinflammatory cytokines were carried out. Tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-8, interleukin-15, leukemia inhibitory factor, epithelial neutrophil-activating peptide 78, regulated upon activation, normal T-cell expressed and secreted, and growth-regulated oncogene-alpha were analyzed in the follicular fluid and compared between women with (n =47) and without endometriosis (n = 279). RESULTS: The above cytokines were detected in the follicular fluid samples. Epithelial neutrophil-activating peptide 78 levels were significantly higher in follicular fluid from endometriosis patients than from controls (p = 0.008). Increases (to twice the control level) were also observed for tumor necrosis factor-alpha and for interleukin-6. CONCLUSIONS: Increased follicular fluid levels of epithelial neutrophil-activating peptide 78, tumor necrosis factor-alpha and interleukin-6 indicate that these cytokines may influence oocyte quality and fecundability of women with endometriosis by deteriorating the microenvironment in the human follicle.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Chemokines, CXC Endometriosis Follicular Fluid Adult Biomarkers Chemokine CXCL5 Chemokines, CXC Endometriosis Endometriosis Female Fertility Follicular Fluid Humans Interleukin-6 Interleukin-6 Oocytes Ovarian Follicle Ovarian Follicle Tumor Necrosis Factor-alpha

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

Cited by (34)

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