L-carnitine supplementation reduces oocyte cytoskeleton damage and embryo apoptosis induced by incubation in peritoneal fluid from patients with endometriosis

Gihan Mansour, Mansour G, Abdelrazik H, H. Abdelrazik, Hussein Abdelrazik, Rakesh K Sharma, Rakesh Sharma, Radwan E, E. Radwan, Emad Radwan, Falcone T, Tommaso Falcone, Agarwal A, Ashok Agarwal
Fertility and sterility · 2008 · vol. 91(5) , pp. 2079–2086 · doi:10.1016/j.fertnstert.2008.02.097 · PMID:18394615 · W2148379108
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L-carnitine supplementation protected oocytes and embryos from damage and apoptosis caused by incubation in peritoneal fluid from women with endometriosis.

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Abstract

ObjectiveTo investigate the protective effect of L-carnitine (LC) against deleterious substances present in the peritoneal fluid (PF) of patients with endometriosis, which may affect the oocyte cytoskeleton and embryogenesis.DesignExperimental study.SettingResearch embryology laboratory at an academic hospital.Patient(s)Frozen metaphase II mouse oocytes and embryos.Intervention(s)One hundred metaphase II mouse oocytes were divided into five groups and incubated: PF from endometriosis patients; PF from endometriosis patients + LC; PF from tubal ligation patients (patient control); LC only; and human tubal fluid (HTF) alone. A total of 180 eight-cell mouse embryos were divided into: endometriosis only; tubal ligation only; endometriosis + LC; LC alone; and HTF alone.Main outcome measure(s)Protective effect of LC on oocytes and embryos.Result(s)Incubation of the oocytes and the embryos with PF from patients with endometriosis statistically significantly damaged the oocyte microtubules and chromosomes and increased embryo apoptosis compared with controls. Incubation with LC (0.6 mg/mL) statistically significantly improved microtubule and chromosome structure and decreased the level of embryo apoptosis.Conclusion(s)We propose the use of LC as a supplement in patients with endometriosis, a novel approach that may help improve in vitro fertilization outcome in these patients.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Carnitine Embryo, Mammalian Endometriosis Oocytes Animals Apoptosis Apoptosis Ascitic Fluid Carnitine Embryo, Mammalian Embryo, Mammalian Embryo, Mammalian Endometriosis Female Humans Laparoscopy Mice Microscopy, Confocal Microtubules

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