Correction: IL-6 and Mouse Oocyte Spindle

Jashoman Banerjee, Rakesh Kumar Sharma, Ashok Agarwal, Dhiman Maitra, Michael P. Diamond, Husam M. Abu‐Soud
In: PLoS ONE · 2012 · vol. 7(5) · doi:10.1371/annotation/947afede-1969-4061-a535-164655e9de72 · W1964093919
article OA: gold CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-28 ⓘ

This study demonstrated that recombinant mouse IL-6 causes a dose-dependent deterioration in microtubule and chromosomal alignment in mouse oocytes, suggesting a mechanism for IL-6-associated infertility.

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This publication is a correction notice for a previously reported study about IL-6 and the mouse oocyte spindle, specifically addressing an error in Figure 3 where the panels were incorrectly labeled. It states that the corrected Figure 3 is provided via a link. The notice does not describe new experiments, methods, or biological findings beyond the figure labeling correction, and it includes no additional limitations. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Interleukin 6 (IL-6) is considered a major indicator of the acute-phase inflammatory response. Endometriosis and pelvic inflammation, diseases that manifest elevated levels of IL-6, are commonly associated with higher infertility. However, the mechanistic link between elevated levels of IL-6 and poor oocyte quality is still unclear. In this work, we explored the direct role of this cytokine as a possible mediator for impaired oocyte spindle and chromosomal structure, which is a critical hurdle in the management of infertility. Metaphase-II mouse oocytes were exposed to recombinant mouse IL-6 (50, 100 and 200 ng/mL) for 30 minutes and subjected to indirect immunofluorescent staining to identify alterations in the microtubule and chromosomal alignment compared to untreated controls. The deterioration in microtubule and chromosomal alignment were evaluated utilizing both fluorescence and confocal microscopy, and were quantitated with a previously reported scoring system. Our results showed that IL-6 caused a dose-dependent deterioration in microtubule and chromosomal alignment in the treated oocytes as compared to the untreated group. Indeed, IL-6 at a concentration as low as 50 ng/mL caused deterioration in the spindle structure in 60% of the oocytes, which increased significantly (P,0.0001) as IL-6 concentration was increased. In conclusion, elevated levels of IL-6 associated with endometriosis and pelvic inflammation may reduce the fertilizing capacity of human oocyte through a mechanism that involves impairment of the microtubule and chromosomal structure.
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Figures There was an error in Figure 3. The panels were labeled incorrectly. The correct Figure 3 can be viewed here: Citation: Banerjee J, Sharma R, Agarwal A, Maitra D, Diamond MP, Abu-Soud HM (2012) Correction: IL-6 and Mouse Oocyte Spindle. PLoS ONE 7(5): 10.1371/annotation/947afede-1969-4061-a535-164655e9de72. https://doi.org/10.1371/annotation/947afede-1969-4061-a535-164655e9de72 Published: May 17, 2012 Copyright: © 2012 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Competing interests: No competing interests declared.

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Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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