Decreased natural killer cell activity in endometriosis patients: relationship to disease pathogenesis
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Natural killer cell activity was significantly reduced in patients with severe endometriosis (stages III and IV), suggesting this may be related to the development of larger lesions rather than an initial cause.
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Abstract
A number of reports have measured NK cell activity in patients with endometriosis with varied results. Therefore we have examined the NK activity of PBL from 44 gynecological patients undergoing laparoscopy. This analysis has demonstrated a significant reduction in NK activity only in more severe stages of endometriosis (stages III and IV) relative to patients with milder disease and controls. These data indicate that decreased NK activity is unlikely to be a primary etiological factor in the development of endometriosis but may indicate that decreased NK activity is related to the development of the more frequent and/or larger lesions characteristic of severe endometriosis. These data could indicate potential for immunotherapy of patients with advanced endometriosis by the upregulation of NK activity in vivo.
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Cited by (4)
- Endometriosis: epidemiology and aetiological factors 2004
- Role of cytokines in endometriosis 2001
- Serum galectin-9 as a noninvasive biomarker for the detection of endometriosis and pelvic pain or infertility-related gynecologic disorders 2017
- Endométriose : l’augmentation des concentrations d’interleukine-1β et d’interleukine-1sRII dans le sérum est associée à la forme profonde de cette pathologie 2014
Cited by (4)
- Serum galectin-9 as a noninvasive biomarker for the detection of endometriosis and pelvic pain or infertility-related gynecologic disorders 2017
- Endométriose : l’augmentation des concentrations d’interleukine-1β et d’interleukine-1sRII dans le sérum est associée à la forme profonde de cette pathologie 2014
- Endometriosis: epidemiology and aetiological factors 2004
- Role of cytokines in endometriosis 2001
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- europepmc
- last seen: 2026-09-14T06:17:53.580500+00:00
- pubmed
- last seen: 2026-05-13T22:11:24.284338+00:00
- unpaywall
- last seen: 2026-05-14T19:30:52.867331+00:00
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine