Gynecological Symptoms Correlated with Immunohistochemical Aspects of Endometriosis and Adenomyosis

Roxana Cleopatra Penciu, Iulia Postolache, Andrei Adrian Tica, Liliana Steriu, Silvia Izvoranu, Diana Mocanu, Vasile Sârbu, Oana Sorina Tica, Mariana Deacu, Gabriela Izabela Bălţătescu, Lucian Cristian Petcu, Irina Tica, Vlad Tica
In: Revista de Chimie · 2019 · vol. 70(8) , pp. 3053–3057 · doi:10.37358/rc.19.8.7486 · W3005176620
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This study examined CD10, CD34, and Ki67 markers in endometriosis and adenomyosis patients, finding pelvic pain correlates with more aggressive disease and dysmenorrhea with angiogenesis.

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Abstract

Endometriosis is a benign disease characterized by the presence of endometrial tissue outside the uterus. It is more associated to chronic pelvic pain, dysmenorrhea and dyspareunia. Adenomyosis is represented by the presence of endometrial tissue inside the uterine muscle. We studied, in 100 successive patients, immunohistochemical markers CD10, CD34 and KI67 in glandular and in stromal cells, in order to assess the correlation between symptoms and them. We did not find any data reporting these aspects. As CD34 is an angiogenesis marker and Ki67 is an aggressivity marker, pelvic pain could predict a more aggressive disease and with a higher spreading capacity in patients with endometriosis. In the same patients, and dysmenorrhea seems to be related with only with angiogenesis.

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Condition tags

endometriosisadenomyosischronic_pelvic_paindysmenorrheadyspareunia

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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