CD10 is useful in demonstrating endometrial stroma at ectopic sites and in confirming a diagnosis of endometriosis
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This case report describes a 29-year-old woman diagnosed with Langerhans cell histiocytosis based on cervical stroma eosinophilia and histiocyte atypia identified via immunohistochemistry.
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Abstract
A rare presentation of a rare disease A 29 year old woman presented to the gynaecology services with a history of cervical smear cytology and punch biopsy showing human papillomavirus related changes, associated with moderate dyskaryosis. She had undergone laser loop excision biopsy of the transformation zone (LLETZ) two years before for previous abnormal smears. This showed moderate dysplasia in the ectocervical epithelium, but was otherwise unremarkable. A second laser loop biopsy was performed. This was received in the histopathology department in two pieces, 1.5 and 1.2 cm in greatest dimension, respectively. On microscopic examination, focal mild squamous dysplasia was identified in each piece. However, in addition to this numerous eosinophils were seen in the cervical stroma. On close inspection, these were admixed with histiocytic cells, the nuclei of which displayed a degree of atypia, with a convoluted shape (see figs 1 and 2 for low and high power views, respectively). Immunuhistochemistry revealed these cells to be positive both for S100 protein (fig A diagnosis of Langerhans cell histiocytosis (LCH) was made.
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Cited by (16)
- Endometriosis of the umbilicus in a 36-year-old woman: a case report and literature review 2023
- Korean Red Ginseng attenuates Di-(2-ethylhexyl) phthalate-induced inflammatory response in endometrial cancer cells and an endometriosis mouse model 2021
- Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study 2019
- Gynecological Symptoms Correlated with Immunohistochemical Aspects of Endometriosis and Adenomyosis 2019
- Endometriosis — insights into a multifaceted entity 2018
- Molecular and Cellular Pathogenesis of Endometriosis 2017
- Two Cases of Polypoid Endometriosis: An Uncommon Variant of Endometriosis 2014
- Sentinel Lymph Node Labeling of Patients with Deep Infiltrating Rectovaginal Endometriosis – Does this Make Sense? 2010
- Sentinel lymph node labeling of patients with deep infiltrating rectovaginal endometriosis – does thismake sense? 2010
- Sentinel Lymph Node Labeling of Patients with Deep Infiltrating Rectovaginal Endometriosis – Does this Make Sense? 2010
- Anatomic Significance of a Positive Barium Enema in Deep Infiltrating Endometriosis of the Large Bowel 2009
- Estrogen and progestogen receptor positive endometriotic lesions and disseminated cells in pelvic sentinel lymph nodes of patients with deep infiltrating rectovaginal endometriosis: a pilot study 2008
- Immunohistochemical analysis of an ectopic endometriosis in the uterine round ligament. 2006
- Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity 2006
- Contribution to the physiopathology, symptomatology and treatment of deep infiltrating endometriosis 2004
- Preferential infiltration of large bowel endometriosis along the nerves of the colon 2004
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- europepmc
- last seen: 2026-07-27T06:15:28.040536+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:13:01.552487+00:00
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