Immunohistochemical analysis of an ectopic endometriosis in the uterine round ligament.

Shinichi Terada, Yachiyo Miyata, Hiroaki Nakazawa, Takamitsu Higashimori, Takanari Arai, Yuji Kikuchi, Motohiro Nozaki
Diagnostic pathology · 2006 · vol. 1(1) , pp. 27 · doi:10.1186/1746-1596-1-27 · PMID:16961927 · PMC1570479 · W2114554470
article OA: gold CC0 ⤵ 16 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study characterized an ectopic endometriosis in the uterine round ligament using immunohistochemistry, finding positive staining for CD125, CD10, estrogen receptor, progesterone receptor, and COX-2, suggesting these markers improve diagnostic accuracy.

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Abstract

A rare case of the inguinal endometriosis was reported with immunohistochemical analysis. A 28-year-old woman had a thumb-sized tumor in the right groin for two years with a gradual increase in size and pain. An operation revealed an elastic hard tumor with an unclear margin and adhesion to the uterine round ligament. The histology showed irregular proliferation of the endometrial glands and stroma. The glandular epithelium stained weakly positive against CD125 antibody and the stromal matrix stained strongly positive against CD10 antibody. The nucleus in both the epithelial and stromal cells stained strongly positive against progesterone and estrogen receptor antibodies, and the cytoplasm in both types of cells stained moderately positive against COX-2 (cyclooxygenase-2) antibody. In conclusion, the combination of estrogen or progesterone receptor antibody for the nucleus and CD10 or COX-2 antibody for the cytoplasm could enhance the accuracy of diagnosis for ectopic endometriosis.

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endometriosis

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