Associations between internal exposure levels of persistent organic pollutants in adipose tissue and deep infiltrating endometriosis with or without concurrent ovarian endometrioma

Stéphane Ploteau, Ploteau S, German Cano-Sancho, Germán Cano-Sancho, Volteau C, Christelle Volteau, Legrand A, Arnaud Legrand, Anaïs Vénisseau, Vénisseau A, Vacher V, Vincent Vacher, Marchand P, Philippe Marchand, Le Bizec B, Bruno Le Bizec, Jean‐Philippe Antignac, Jean-Philippe Antignac
Environment international · 2017 · vol. 108 , pp. 195–203 · doi:10.1016/j.envint.2017.08.019 · PMID:28869876 · W2753540656
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This study measured internal exposure levels of persistent organic pollutants in adipose tissue and analyzed their association with deep infiltrating endometriosis, with or without concurrent ovarian endometrioma.

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Abstract

Endometriosis is a gynaecological disease characterized by the presence of ectopic endometrial tissue. Histologically, it appears as different sub-types, being peritoneal endometriosis, ovarian endometrioma (OvE) and deep infiltrating endometriosis (DIE), which are of major relevance due to their varying clinical presentations. A number of persistent organic pollutants (POPs) have been associated with the onset of endometriosis, yet the overall set of existing studies remains fairly divergent. In this preliminary case-control study we aimed to assess the potential associations between the internal exposure to POPs and the presence of DIE with or without concurrent OvE. Adipose tissue and serum samples were collected from surgically confirmed cases (n=55) and controls (n=44) enrolled during 2013 and 2015 in Pays de la Loire, France. Targeted pollutants (76 historical or more emerging POPs including dioxins, polychlorobiphenyls (PCB), polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), hexabromocyclododecanes (HBCDs) and organochlorine pesticides (OCPs) were quantified by chromatography coupled to mass spectrometry. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated from unconditional logistic regression adjusted for known confounding variables. The results showed significant associations between DIE and adipose tissue levels of 1.2.3.7.8 - PeCDD, OCDF, PCB 105, 114, 118 and 123, PBDE 183, PBB 153, and several OCPs including trans‑nonachlor, cis‑heptachlor epoxide, dieldrin, β-hexachlorocyclohexane and hexachlorobenzene. The largest associations were observed for OCDF followed by cis‑heptachlor epoxide, exhibiting adjusted ORs (95% CI) of 5.42 (2.73-12.85) and 5.36 (2.44-14.84) per 1-SD increase, respectively. The stratified analysis comparing both disease sub-types suggested that adipose tissue exposure markers may be more associated with DIE concurrent with OvE, however these results need to be confirmed in a larger population.

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Condition tags

endometriosisdie_deep_infiltratingendometrioma

MeSH descriptors

Adipose Tissue Endometriosis Environmental Exposure Environmental Pollutants Adipose Tissue Adult Case-Control Studies Endocrine Disruptors Endocrine Disruptors Endometriosis Environmental Pollutants Environmental Pollutants Female Humans Pesticides Pesticides Pesticides

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