Environmental and host-associated risk factors in endometriosis and deep endometriotic nodules: A matched case–control study

Heilier JF, Jean-François Heilier, Donnez J, Jacques Donnez, Fabienne Nackers, Réjane Rousseau, Rousseau R, Verougstraete V, Violaine Verougstraete, Katrin Rosenkranz, Rosenkranz K, Donnez O, Olivier Donnez, Grandjean F, Frédéric Grandjean, Dominique Lison, Tonglet R, René Tonglet
Environmental research · 2006 · vol. 103(1) , pp. 121–129 · doi:10.1016/j.envres.2006.04.004 · PMID:16781705 · W2017424272
article OA: closed CC0 ⤵ 85 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This case-control study investigated environmental and host-associated risk factors associated with endometriosis and deep endometriotic nodules in affected individuals.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Peritoneal endometriosis (PE) and deep endometriotic nodules (DEN) are gynecological diseases recently shown to be associated with elevated serum concentrations of organochlorines. The objective of the present study was to compare risk factors associated with both forms of the disease, with a particular attention to potential sources of organochlorine exposure. This matched case-control study with prospective recruitment included 88 triads (PE-DEN-control). All women were face-to-face interviewed with a standardized questionnaire, and serum dioxin and polychlorinated biphenyl measurements were available for 58 of them. Alcohol consumption (odds ratio (OR): 5.82 [confidence interval at 95% (95%CI) 1.20-28.3]) in DEN and low physical activity at work for DEN (OR: 4.58 [95%CI 1.80-11.62]) and PE (OR: 5.61 [95%CI 1.90-16.60]) were traced as significant risk factors. Organochlorine-related factors (use of tampons, occupational or environmental exposure) were not related to the disease. The current consumption of foodstuffs that were more likely to contribute to organochlorine body burden did not differ among the groups. Only some of these fatty foodstuffs (marine fish, pig meat) were traced by multiple regression analysis as significant determinants of organochlorine body burden, explaining only a small fraction (20%) of the interindividual variation of organochlorine body burden. We conclude that PE and DEN share similar patterns of risk or protective factors.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Alcohol Drinking Endometriosis Motor Activity Uterine Diseases Adult Alcohol Drinking Belgium Belgium Benzofurans Benzofurans Case-Control Studies Contraceptives, Oral Contraceptives, Oral Dibenzofurans, Polychlorinated Dietary Fats Endometriosis Endometriosis Endometriosis Environmental Exposure Environmental Pollutants

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (57)

Cited by (50)

Source provenance

europepmc
last seen: 2026-07-26T06:08:39.051465+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:15:18.313808+00:00
License: CC0 · commercial use OK