Epidemiologic determinants of endometriosis: A hospital-based case-control study

Signorello LB, Lisa B. Signorello, L B Signorello, Bernard L. Harlow, B L Harlow, Cramer DW, D. W. Cramer, Daniel W. Cramer, Spiegelman D, Donna Spiegelman, D Spiegelman, Joseph A. Hill, J A Hill, Hill JA
Annals of epidemiology · 1997 · vol. 7(4) , pp. 267–274 · doi:10.1016/s1047-2797(97)00017-3 · PMID:9177109 · W2010816914
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This hospital-based case-control study identified epidemiologic factors associated with endometriosis by comparing characteristics of affected women to unaffected controls.

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Abstract

PurposeRisk factors for endometriosis were identified through data obtained from a case-control study at Brigham and Women's Hospital in Boston, Massachusetts.MethodsCases were 50 women with infertility-associated endometriosis. The primary control group consisted of 89 fertile women without endometriosis, and an alternate control group consisted of 47 infertile women without endometriosis.ResultsThe risk of endometriosis was positively associated with height (OR), 2.8 per 10 cam increase; 95% confidence interval (CI), 1.4-5.6) and inversely associated with weight (OR, 0.7 per 10 kg increase; 95% CI, 0.5-1.0) and body mass index (OR, 0.7 per 5 kg/m2 increase; 95% CI, 0.4-1.1). We observed an inverse association with exercise (OR, 0.6; 95% CI, 0.3-1.5), but the effect was limited to women who exercised > or = 4 hours per week (OR, 0.4; 95% CI, 0.2-1.2). Endometriosis was not associated with either smoking or alcohol consumption.ConclusionsOur findings suggest that the fertility status of controls can strongly influence associations seen with menstrual characteristics. This study is one of few to address the issue of control selection for a case-control study of endometriosis. Specifically, potential problems encountered using fertile and infertile control women are examined and discussed.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Infertility, Female Adult Alcoholism Body Mass Index Case-Control Studies Confidence Intervals Endometriosis Endometriosis Endometriosis Female Humans Incidence Infertility, Female Infertility, Female Life Style Massachusetts Massachusetts Risk Factors Smoking

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