Serum dioxins, polychlorinated biphenyls, and endometriosis: A case-control study in Atlanta

Amanda Sue Niskar, Niskar AS, Amanda S Niskar, Needham LL, Larry L Needham, Carol Rubin, Rubin C, Turner WE, Wayman E Turner, Colleen Martin, Colleen A Martin, Martin CA, Donald G Patterson, Patterson DG Jr, Lisa Hasty, Hasty L, Lisa A. Hasty, Lee-Yang Wong, Wong LY, Michele Marcus, Marcus M
Chemosphere · 2008 · vol. 74(7) , pp. 944–949 · doi:10.1016/j.chemosphere.2008.10.005 · PMID:19027927 · W2090034145
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This case-control study investigated the association between serum levels of dioxins and polychlorinated biphenyls and the presence of endometriosis in women from Atlanta.

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Abstract

Endometriosis among women of reproductive age can result in pain and infertility. The objectives of this study were to test if there is a relation between endometriosis and serum dioxin concentrations as expressed by total toxic equivalence and serum total polychlorinated biphenyl concentrations among women patients at one Atlanta reproductive medicine clinic during 1998-1999; a secondary objective was to provide exposure data for individual congeners of these chemicals and 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (p,p'-DDE) in women in Atlanta. Laparoscopy including biopsy and visualization of the peritoneal cavity, ovaries, outside of the fallopian tubes and uterus confirmed all endometriosis cases (n=60) and confirmed 30 controls without endometriosis. Other controls had an infertile partner (n=27) or ovulation problems (n=7) with no signs or symptoms of endometriosis. All serum samples were analyzed at the U.S. Centers for Disease Control and Prevention in 2003. Statistical analyses included Fisher's exact chi-square tests and logistic regression. Models were presented for the full study sample and for the subset that included all cases (n=60) and only controls (n=30) with surgical confirmation of disease-free status. Serum concentrations (lipid-adjusted and non lipid-adjusted) of analyzed exposure measures were low and similar for cases and controls and did not explain endometriosis in the study population.

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Condition tags

endometriosis

MeSH descriptors

Dioxins Endometriosis Environmental Pollutants Polychlorinated Biphenyls Adult Case-Control Studies Chi-Square Distribution Demography Dichlorodiphenyl Dichloroethylene Dichlorodiphenyl Dichloroethylene Dioxins Endometriosis Endometriosis Environmental Exposure Environmental Pollutants Female Humans Middle Aged Polychlorinated Biphenyls Risk Factors

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