Early Origins of Endometriosis: Role of Endocrine Disrupting Chemicals

Germaine M. Buck Louis
In: Endometriosis · 2011 · pp. 153–163 · doi:10.1002/9781444398519.ch15 · W1498201544
other OA: closed CC0 ⤵ 2 in-corpus citations
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This review explores the role of endocrine-disrupting chemicals in the early developmental origins of endometriosis, proposing the ovarian dysgenesis hypothesis and advocating for a life course approach to research.

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Abstract

Increasing evidence supports an early origin for health and disease, including gynecologic disorders, possibly the result of environmental exposures during critical or sensitive windows of human development. This chapter discusses the weight of human evidence regarding the relation between environmental exposures, particularly the role of endocrine disrupting chemicals, and endometriosis. The ovarian dysgenesis hypothesis is posited to conceptualize the available research findings while suggesting new avenues for research. Lastly, the chapter discusses the relation between early exposures and endometriosis in the context of later onset disease risk associated with an endometriosis diagnosis, underscoring the importance of a life course approach for study.

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endometriosis

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