Estrogen and progesterone receptors in endometriosis

Luiz R Guimarães Ferreira, Luiz Rodrigo Guimaraes Ferreira, Teresa Cristina Santos Cavalcanti, Teresa Cavalcanti, Monica Zomer, Monica Tessmann Zomer, William Kondo, Edward Araujo Júnior, Jaime Kulak Junior, Jaime Kulak
Minerva obstetrics and gynecology · 2021 · vol. 74(4) , pp. 330–336 · doi:10.23736/s2724-606x.21.04888-0 · PMID:34498837 · W3197236367
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that estrogen and progesterone receptors are present in all endometriosis implant locations, with progesterone receptors being significantly more abundant than estrogen receptors, irrespective of hormonal treatment.

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Abstract

BACKGROUND: This study aims to identify the presence of estrogen and progesterone hormone receptors in endometriosis implants and to determine whether hormone treatment influences the receptors in these implants. METHODS: Cross-sectional study with historical data collection. The analysis was conducted on 156 endometriosis implants from 67 patients undergoing endometriosis laparoscopy. The patients were divided into two groups: one group underwent hormone treatment (N.=20) and another group did not receive hormone treatment (N.=47) prior to surgery. Women of reproductive age with clinical pain and/or infertility who were diagnosed with endometriosis and underwent surgery were included. The specimens were analyzed after the estrogen and progesterone hormone receptors underwent immunohistochemistry. RESULTS: All analyzed topographies presented estrogen and progesterone hormone receptors. Progesterone hormone receptor expression was considerably superior to estrogen receptor expression (P<0.001). CONCLUSIONS: Hormone receptors are present in endometriosis implants on the ovarian fossae, uterosacral ligaments, sac fundus, and ovaries. Progesterone receptors predominate in implants, regardless of hormonal treatment.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Hormone Replacement Therapy Receptors, Estrogen Receptors, Estrogen Receptors, Progesterone Receptors, Progesterone Cross-Sectional Studies Female Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Cited by (2)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:24:20.309598+00:00
License: CC0 · commercial use OK