Xiaoyi Yusi decoction improves fertilization and embryo transfer outcomes in patients with endometriosis.

Wen-Jing Jiang, Jiang Wenjing, Jiang Huaying, Yuan Lihua, Lihua Yuan, S A Yuanhong, Xiao Jimei, Hongqi Sun, Sun Hongqi, Song Jingyan, Jing‐Yan Song, Sun Zhengao
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023 · vol. 43(5) , pp. 1026–1033 · doi:10.19852/j.cnki.jtcm.2023.05.006 · PMID:37679991 · W4386529576
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Xiaoyi Yusi decoction improved endometriosis-related infertility outcomes by regulating glycerophospholipid and pyruvate metabolism and the tricarboxylic acid cycle.

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Abstract

OBJECTIVE: To investigate the effect of - Xiaoyi Yusi decoction (XYYSD, ), a Traditional Chinese Medicine (TCM), on fertilization and embryo transfer (IVF-ET) in patients with endometriosis, and to study the mechanism underpinning the action. METHODS: Women who underwent IVF-ET were divided into three groups by simple randomization: the treatment ( 32; with TCM treatment), patient (28; with endometriosis alone), and control (33; with male factor alone) groups. The luteal phase short-acting gonadotropin-releasing hormone agonist prolonged protocol was used in all three groups. To compare the changes in TCM scores and reproductive outcomes before and after TCM intervention in patients with endometriosis, partial least-squares discriminant analysis was used to analyze the follicular fluid samples of each group and screen and compare metabolites using the MetaboAnalyst software. RESULTS: The clinical data indicated that following TCM intervention, kidney deficiency and blood stasis symptom patterns improved dramatically in patients with endometriosis and that their clinical pregnancy rate increased significantly (71.9% 57.1%, 0.05). Metabolomics showed that the two groups of samples were separated before and after TCM intervention. After TCM intervention, the intervention group was close to the control group, indicating that the TCM had a certain effect. Pathway analysis revealed that after TCM intervention, the metabolism of glycerin phospholipid, pyruvate, and citric acid was regulated. CONCLUSIONS: Through the pyruvate and glycerophospholipid metabolism pathways and tricarboxylic acid cycle, the TCM XYYSD successfully improved kidney deficiency and blood stasis symptom pattern, as well as the clinical reproductive outcomes of patients with endometriosis-related infertility.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Citric Acid Citric Acid Citric Acid Citric Acid Citric Acid Citric Acid Citric Acid Citric Acid

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