Altered expression of progesterone receptor isoforms A and B in human eutopic endometrium in endometriosis patients

Wölfler MM, Monika Martina Wölfler, Küppers M, Mareike Küppers, Werner Rath, Rath W, Volker U. Buck, Volker Uwe Buck, Ivo Meinhold-Heerlein, Ivo Meinhold‐Heerlein, I. Claßen-Linke, Irmgard Classen-Linke
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2016 · vol. 206 , pp. 1–6 · doi:10.1016/j.aanat.2016.03.004 · PMID:27050108 · W2316119501
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This study investigated the expression levels of progesterone receptor isoforms A and B in human eutopic endometrium and found alterations in endometriosis patients.

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Abstract

Recent data implicate an altered expression of progesterone receptor isoform A (PR-A) and B (PR-B) in the endometrium of endometriosis patients. This prospective exploratory study aimed to precisely determine the PR-A and PR-B expression using immunohistochemical techniques in eutopic endometrium of women with endometriosis compared with disease-free women throughout the menstrual cycle. All symptomatic patients underwent laparoscopy for the diagnosis of endometriosis and histological confirmation of the disease (EO) whereas controls were proven disease-free (CO). In CO samples (n=10) an increased expression of PR-A and PR-B during the proliferative to early secretory phase and a decreased expression of both receptor isoforms during the mid to late secretory phase was ascertained in accordance with previous studies. In patients with endometriosis (n=16) no cycle dependent pattern of PR-A and PR-B expression was identified in contrast to patients without endometriosis. Moreover, in EO samples a huge variety of inter- and intra-individual differences in PR-A and PR-B expression were detected. These data provide further evidence that dysregulation of the PR-A and PR-B expression might contribute to the pathophysiology of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Menstrual Cycle Receptors, Progesterone Adolescent Adult Endometriosis Endometrium Female Gene Expression Regulation Humans Menstrual Cycle Middle Aged Receptors, Progesterone Tissue Distribution Young Adult

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