A predictive model for endometriosis

M M Wölfler, Monika Wölfler, Friedrich Nagele, F Nagele, Andrea Kolbus, A Kolbus, Stefan Seidl, S Seidl, Beth Schneider, B Schneider, Johannes Huber, J C Huber, Walter Tschugguel, W Tschugguel
Human Reproduction · 2005 · vol. 20(6) , pp. 1702–1708 · doi:10.1093/humrep/deh796 · PMID:15760962 · W1973337086
article OA: closed CC0 ⤵ 28 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Endometrial aromatase mRNA and protein expression, combined with moderate to severe dysmenorrhea, predicted endometriosis in symptomatic women with 95.5% accuracy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: Aromatase is the key enzyme in the process of estrogen biosynthesis from the precursor androgen. Recently, aromatase has been found to be aberrantly expressed in eutopic endometrium of patients suffering from endometriosis. This finding has prompted speculation about the contribution of this enzyme to the prediction of this disease. METHODS: We prospectively aimed to evaluate whether endometrial biopsy, prior to laparoscopy in symptomatic women to screen for the presence of aromatase by real-time RT-PCR and immunohistochemistry, combined with select patients' characteristics, is of value to predict endometriosis. RESULTS: Of 48 consecutive symptomatic and eligible patients, 25 (52.1%) exhibited endometriosis and 23 (47.9%) were disease-free. A multiple logistic regression model revealed that 95.5% of patients whose eutopic endometrium was found to be positive for aromatase mRNA as well as immunohistochemically detected protein and who were additionally suffering from moderate to severe dysmenorrhoea (visual analogue scale score >4/10) exhibited endometriosis at laparoscopy. CONCLUSIONS: These findings provide direct evidence that screening for eutopic endometrial aromatase in combination with clinical data could be of discriminative value in the prediction of disease.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosisdysmenorrhea

MeSH descriptors

Aromatase Endometriosis Adult Aged Aromatase Biopsy Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Middle Aged Predictive Value of Tests Prospective Studies Regression Analysis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

Cited by (28)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:15:41.664291+00:00
License: CC0 · commercial use OK