A predictive model for endometriosis

Monika Wölfler, M M Wölfler, Wölfler MM, Nagele F, F. Nagele, Friedrich Nagele, A Kolbus, Andrea Kolbus, Kolbus A, S Seidl, Stefan Seidl, Seidl S, Beth Schneider, B Schneider, Schneider B, Johannes Huber, J C Huber, Huber JC, Walter Tschugguel, Tschugguel W, W Tschugguel
Human Reproduction · 2005 · vol. 20(6) , pp. 1702–1708 · doi:10.1093/humrep/deh796 · PMID:15760962 · W1973337086
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Endometrial aromatase mRNA and protein expression, combined with moderate to severe dysmenorrhea, predicted endometriosis in symptomatic women with 95.5% accuracy.

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Abstract

BACKGROUND: Aromatase is the key enzyme in the process of estrogen biosynthesis from the precursor androgen. Recently, aromatase has been found to be aberrantly expressed in eutopic endometrium of patients suffering from endometriosis. This finding has prompted speculation about the contribution of this enzyme to the prediction of this disease. METHODS: We prospectively aimed to evaluate whether endometrial biopsy, prior to laparoscopy in symptomatic women to screen for the presence of aromatase by real-time RT-PCR and immunohistochemistry, combined with select patients' characteristics, is of value to predict endometriosis. RESULTS: Of 48 consecutive symptomatic and eligible patients, 25 (52.1%) exhibited endometriosis and 23 (47.9%) were disease-free. A multiple logistic regression model revealed that 95.5% of patients whose eutopic endometrium was found to be positive for aromatase mRNA as well as immunohistochemically detected protein and who were additionally suffering from moderate to severe dysmenorrhoea (visual analogue scale score >4/10) exhibited endometriosis at laparoscopy. CONCLUSIONS: These findings provide direct evidence that screening for eutopic endometrial aromatase in combination with clinical data could be of discriminative value in the prediction of disease.

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Condition tags

endometriosisdysmenorrhea

MeSH descriptors

Aromatase Endometriosis Adult Adult Aged Aged Aromatase Aromatase Biopsy Biopsy Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (28)

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License: CC0 · commercial use OK