High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome

Brosens J, Jan Brosens, Jan J. Brosens, Verhoeven H, Hugo Verhoeven, Campo R, Rudi Campo, Luca Gianaroli, Stephan Gordts, Gordts S, Hazekamp J, Johan Hazekamp, Hägglund L, Leif Hägglund, Tonko Mardesic, Mardesic T, Varila E, Eero Varila, Zech J, Josef Zech, Ivo Brosens, Brosens I
Human Reproduction · 2004 · vol. 19(2) , pp. 352–356 · doi:10.1093/humrep/deh075 · PMID:14747179 · W2153331470
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High expression of aromatase P450 mRNA in the endometrium was associated with a lower clinical pregnancy rate in women undergoing IVF treatment.

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Abstract

BACKGROUND: The success of IVF treatment is dependent upon embryo quality and coordinated growth and differentiation of the endometrium. Aromatase P450 expression in the human endometrium is thought to be restricted to women with proliferative reproductive tract disorders such as endometriosis, leiomyomas and adenomyosis. METHODS: To determine whether endometrial aromatase P450 mRNA expression is prognostic of IVF outcome, we quantified transcript levels in biopsy specimens from a cohort of subfertile patients awaiting IVF treatment using real-time quantitative PCR. RESULTS: Aromatase P450 transcripts were detected in all endometria examined, although the levels varied considerably between samples, ranging from 0.22 to 486.6 arbitrary units (a.u.). The clinical pregnancy rate in women with high endometrial aromatase P450 mRNA levels (> or = 8.3 a.u.; n = 21) was 9.5% compared with 30.1% in those patients with low expression levels (<8.3 a.u.; n = 101) (P < 0.05). The cycle day of the endometrial biopsy, cause of infertility, age, parity, number of oocytes collected and number of embryos transferred did not differ between patients with high versus low endometrial aromatase P450 mRNA levels (P > 0.1). CONCLUSIONS: Our results indicate that endometrial P450 mRNA levels can identify women at increased risk of IVF treatment failure.

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Condition tags

endometriosisadenomyosisinfertility

MeSH descriptors

Aromatase Endometrium Fertilization in Vitro Gene Expression RNA, Messenger Treatment Outcome Aromatase Aromatase Embryo Transfer Endometrium Female Humans Infertility Infertility Polymerase Chain Reaction RNA, Messenger

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