Decreased Glycolysis Due to Lactate Dehydrogenase A N6-Methyladenosine Methylation in Endometrium of Endometriosis Impairs Its Decidualization and Contributes to Related Infertility

Ruey-Ling Weng, Ruiweng Weng, Weng R, Liu Y, Yi Liu, Wenqian Xiong
The American Journal of Pathology · 2025 · vol. 195(12) , pp. 2431–2450 · doi:10.1016/j.ajpath.2025.08.016 · PMID:41016545 · W4414575132
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Lactate dehydrogenase A N6-methyladenosine methylation in the endometrium of endometriosis patients reduces glycolysis, impairs decidualization, and contributes to infertility.

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Abstract

Endometriosis-related infertility is a prevalent reproductive health concern of global significance. Functional abnormalities of the endometrium are increasingly recognized as a pivotal contributor to infertility in affected individuals. In the present study, a significant reduction in glycolytic activity was observed in secretory-phase endometrial tissues obtained from patients with endometriosis, and this metabolic defect was attributed to down-regulated expression of lactate dehydrogenase A (LDHA). This impaired glycolysis was found to induce defective endometrial decidualization and contribute to endometriosis-related infertility in a mouse model. Mechanistically, inhibition of LDHA promoted the production of reactive oxygen species and apoptosis of endometrial stromal cells, ultimately resulting in compromised stromal cell decidualization. Furthermore, reduced LDHA expression was confirmed in the eutopic endometrium of patients with endometriosis, which was associated with decreased N6-methyladenosine (m6A) demethylation activity. This attenuation of m6A demethylation was, in turn, attributed to the down-regulated expression of alkB homolog 5-a key enzyme responsible for m6A demethylation modification. Collectively, the findings demonstrate that elevated m6A methylation levels in the eutopic endometrium of patients with endometriosis impair endometrial glycolytic metabolism and decidualization of endometrial stromal cells, thereby contributing to endometriosis-related infertility. This pathologic cascade is mediated by the down-regulation of LDHA expression.

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Condition tags

endometriosisinfertility

MeSH descriptors

Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine Adenosine

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Cited by (2)

SciLite annotations

chemicals 3
methyladenosine oxygen methyladenosine
organisms 1
transgenic mice

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