Altered expression of progesterone receptor isoforms A and B in human eutopic endometrium in endometriosis patients

Wölfler MM, Monika Martina Wölfler, Küppers M, Mareike Küppers, Werner Rath, Rath W, Volker U. Buck, Volker Uwe Buck, Ivo Meinhold-Heerlein, Ivo Meinhold‐Heerlein, I. Claßen-Linke, Irmgard Classen-Linke
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2016 · vol. 206 , pp. 1–6 · doi:10.1016/j.aanat.2016.03.004 · PMID:27050108 · W2316119501
Observational OA: closed CC0 ⤵ 22 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study investigated the expression levels of progesterone receptor isoforms A and B in human eutopic endometrium and found alterations in endometriosis patients.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Recent data implicate an altered expression of progesterone receptor isoform A (PR-A) and B (PR-B) in the endometrium of endometriosis patients. This prospective exploratory study aimed to precisely determine the PR-A and PR-B expression using immunohistochemical techniques in eutopic endometrium of women with endometriosis compared with disease-free women throughout the menstrual cycle. All symptomatic patients underwent laparoscopy for the diagnosis of endometriosis and histological confirmation of the disease (EO) whereas controls were proven disease-free (CO). In CO samples (n=10) an increased expression of PR-A and PR-B during the proliferative to early secretory phase and a decreased expression of both receptor isoforms during the mid to late secretory phase was ascertained in accordance with previous studies. In patients with endometriosis (n=16) no cycle dependent pattern of PR-A and PR-B expression was identified in contrast to patients without endometriosis. Moreover, in EO samples a huge variety of inter- and intra-individual differences in PR-A and PR-B expression were detected. These data provide further evidence that dysregulation of the PR-A and PR-B expression might contribute to the pathophysiology of endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Menstrual Cycle Receptors, Progesterone Adolescent Adolescent Adult Adult Endometriosis Endometriosis Endometrium Endometrium Female Female Gene Expression Regulation Gene Expression Regulation Humans Humans Menstrual Cycle Menstrual Cycle

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (22)

Source provenance

europepmc
last seen: 2026-10-16T06:09:50.462052+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:17:32.889250+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK